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SECI Oncology Journal /
بيانات الدورية
أعداد قيد الطبع
اعداد الدورية
  SECI Oncology Journal /
  
 

[9002918.] رقم البحث : 9002918 -
Dexmedetomidine versus midazolam as an adjuvant sedating agent for bone marrow aspiration in pediatric patients. /
تخصص البحث : General
  SECI Oncology Journal / / vol.7 - 31/12/2019
  تاريخ تقديم البحث 02/06/2019
  تاريخ قبول البحث 16/06/2019
  عدد صفحات البحث 7
  ندي طلعت فرغلي محمد
  محمد حسين محمد الجاسر - مؤلف رئيسي
  Sedation, Bone marrow biopsy, ketamine, Midazolam, Dexmeditomidine
  Background: Bone marrow aspiration/biopsy, in patients with hematological cancer, is a painful procedure and
may be repeated at regular intervals, so we compared the effects of two different sedative agents (Midazolam
and Dexmedetomidine) on haemodynamic, sedation and recovery profile in child patients undergoing bone
marrow aspiration/biopsy under conscious sedation with ketamine.
Methods: 100 Child aged 3–12 years with haematological diseases were enrolled in this randomized, double
blind study, divided into two groups:
group I: Patients received midazolam (IV infusion) 0.05 mg/kg. group II: Patients received Dexmedetomidine
(IV infusion) 0.75 µg/kg and all patients received Ketamine 1 mg/kg intravenously (IV). We started
Dexmedetomidine or midazolam infusion over 10 minutes through a peripheral venous cannula, and then 5
minutes from the start, ketamine was administered over 10–20 seconds. In both groups’ hemodynamics, sedation
times and Ramsay scores are obtained.
Results: Both dexmedetomidine -ketamine and midazolam-ketamine combinations produce stable
hemodynamics and satisfactory induction conditions in patients with hematological cancer diseases undergoing
bone marrow aspiration. These combinations provide effective sedation with only few side effects and minor
hemodynamic fluctuations. With longer sedation time and recovery time were recorded in dexmedetomidine
group versus midazolam group.
Conclusion: Dexmedetomidine ketamine is a better sedative combination than midazolam-ketamine and both
preserve hemodynamics stable.
Trial registeration.gov NCT03647579
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[9003070.] رقم البحث : 9003070 -
Assessment of the Use of 8 color Flowcytometry in the Diagnosis of Acute Leukemia /
تخصص البحث : General
  SECI Oncology Journal / / vol.7 - 31/12/2019
  تاريخ تقديم البحث 04/09/2019
  تاريخ قبول البحث 07/09/2019
  عدد صفحات البحث 13
  ندي طلعت فرغلي محمد
  ياسمين حسام الدين مادى - مؤلف رئيسي
  Acute leukemia, multicolor immunophenotyping, 8 color flow cytometry
  Background: Immunophenotyping has become a necessity in the diagnosis and classification of hematological neoplasms. It is a reliable, time saving and accurate method for not only the diagnosis but also for detection of minimal residual disease. There are ongoing developments in the field of flow cytometry in which more advanced flow cytometers have been developed allowing multicolor immunophenotyping. The question is; are they practically applicable or are they just for research purposes. Methods: This study was conducted on 71 newly diagnosed acute leukemia patients. Samples were analyzed by using the 4 color FACS Calibur and 8 color FACS Canto II. Results: There was significant difference between the sample volume required, monoclonal antibodies, number of tubes used and the turnaround time for each sample on comparing the 8 color flow cytometer to the 4 color flow cytometer.

Conclusion: It has been concluded that 8 multicolor flow cytometer definitely has the upper hand in time saving and reagents saving without the need to repeat the use of mono clonal antibodies. It also includes the leukemia associated phenotypes and aberrancies that would be missed when using the 4 color panel. However, there are certain drawbacks including technical difficulties and the requirement of high level of capability.
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[9003071.] رقم البحث : 9003071 -
Billroth II with Braun Enteroenterostomy vs. Roux en Y Reconstruction Post Distal Gastrectomy /
تخصص البحث : General
  SECI Oncology Journal / / vol.7 - 31/12/2019
  تاريخ تقديم البحث 04/09/2019
  تاريخ قبول البحث 04/09/2019
  عدد صفحات البحث 9
  ندي طلعت فرغلي محمد
  محمد عبد الله صالح - مؤلف رئيسي
  Gastric cancer, distal gastric cancer, distal gastrectomy, Billroth II, Braun Enteroenterostomy and Roux-en-Y.
  Background: Roux-en-Y reconstruction is superior to Billroth-II; it is an important factor that improves quality of life. Is modification (Braun enteroenterostomy) in Billroth-II has similar or superior effect?? Materials and methods: This study includes 34 operable patients who subjected to radical distal gastrectomy with D1 and D2 lymphadenectomy between May 2014 and Jan. 2017 at surgical oncology department, South Egypt Cancer Institute. Billroth-II with Braun enteroenterostomy versus Roux-en-Y reconstruction where done (post gastrectomy). Results: Mean operative time was 167 min (SD ±60) in Billroth-II-Braun vs. 192 min (SD ±64) in Roux-en-Y, mean blood loss was 490(SD±200) ml in Billroth-II-Braun vs. in Roux-en-Y 413(SD±232) ml, Hospital stay was 14(±5) days in Billroth-II-Braun vs. 16(±7) days in Roux-enY, all of them with p value > 0.05. Anastomotic leak occurred in 1 in Billroth-II-Braun vs. 2 in Roux-en-Y while surgical site infection occurred in 8 cases in Billroth-II-Braun and 3 in Roux-enY, pneumonia 1 case in Billroth-II-Braun and 2 in Roux-en-Y, DVT and PE 2 cases in Billroth-IIBraun p value > 0.05. The majority of dumping (early and late) occur in 7 cases in Roux-en-Y group and biliary reflux occurs in 12% of cases (1 in Billroth-II-Braun and 3 in Roux-en-Y) with p value = 0.043. Thirty-day mortality occurs in 2 cases in Billroth-II-Braun and 2 in Roux-en-Y with p value > 0.05. Anastomotic recurrence occurs in 4 cases in Billroth-II-Braun while 4 in Roux-en-Y, one case develop anastomotic. Regional lymph nodes metastasis in 1 in Billroth-IIBraun), and distant metastasis in 7 in Billroth-II-Braun and 3 in Roux-en-Y, local and distant metastasis in 2 in Billroth-II-Braun and 1 in Roux-en-Y, the mortality was 9 cases of Billroth-IIBraun, 3 in Roux-en-Y during follow up, p value > 0.05. Median of overall and disease free survival in both groups 16 months and 11 months respectively with p value > 0.05. Conclusions: Billroth-II with Braun enteroenterostomy is superior to Roux-en-Y reconstruction and improves the motility disorders
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[9003072.] رقم البحث : 9003072 -
Prognostic roles of both CD49d and trisomy12 in chronic lymphocytic leukemia (CLL) /
تخصص البحث : General
  SECI Oncology Journal / / vol.7 - 31/12/2019
  تاريخ تقديم البحث 04/09/2019
  تاريخ قبول البحث 08/09/2019
  عدد صفحات البحث 8
  ندي طلعت فرغلي محمد
  اسماء احمد محمد - مؤلف رئيسي
  Chronic lymphocytic leukemia, CD49d, Trisomy12.
  Introduction: chronic lymphocytic leukemia (CLL) is considered the most common type of leukemia in the western world and in Egypt CLL is the most common subtype of leukemia’s. The National Cancer Registry reported over 80% of lymphoid leukemia’s are CLL. chronic lymphocytic leukemia (CLL) is characterized by heterogeneous clinical course. Therefore, the identification of prognostic and predictive factors for CLL is critical and this is a field of active investigation. Over the past several years, a group of so-called new prognostic factors has been developed. This several prognostic factors associated with the immunophenotypic profile, cytogenetic features and mutational status of the immunoglobulin heavy chain (IGVH). Aim of the work: The aim of this review is to discuss the prognostic role of both CD49d and trisomy12 in chronic lymphocytic leukemia (CLL). Conclusion: Combination of CD49d and trisomy12 may have very strong prognostic roles in the prognosis of CLL and add a prognostic value to CLL patients
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[9003177.] رقم البحث : 9003177 -
T-cell immunoglobulin mucin-3 expression in Acute Myeloid Leukemia: a cross-sectional study /
تخصص البحث : General
  SECI Oncology Journal / / vol.7 - 31/12/2019
  تاريخ تقديم البحث 24/10/2019
  تاريخ قبول البحث 11/11/2019
  عدد صفحات البحث 6
  ندي طلعت فرغلي محمد
  تسنيم شداد رتيب - مؤلف رئيسي
  Acute myeloid leukemia, T-cell immunoglobulin mucin-3
  Background and aim: As acute leukemia’s are characterized by abnormal proliferation of precursor cells simulating normal hematopoietic stem cells (HSC.) It is critical to isolate acute myeloid leukemia stem cells (AML LSCs) from normal HSCs in order to eradicate the AML LSC without killing normal HSCs. This can be done by identifying a molecule that is expressed or functions specifically at the AML LSC stage. This paper is aimed to investigate the role of T-cell immunoglobulin mucin-3 (TIM3) expression on leukemic stem cells of AML patients and to correlate its level with the outcome of the disease. TIM3 was assessed by Flow-cytometer technique Patients and methods: Our study included 30 patients newly diagnosis as acute myeloid leukemia between March 2016 and December 2016. Age ranged from 20 to 68 years old with median age was 32 years. Seventeen cases were males, and 13 cases were females. The Ethical and Research committees approved this study in the South Egypt Cancer Institute. An informed written consent in accordance was taken from all cases. Results: mean expression of TIM3 on CD34+ CD38- LSCs was 48.80 ± 29.70 % with range of 30% to 97% while expression of TIM3 on CD34+ CD38+ LBs was 25.29 ± 18.34 with range of 26% to 67%. Remission occurred in 18 cases (60%) based on morphologic assessment of peripheral blood and bone marrow aspirates. Patients who did not achieve complete remission had significantly higher expression of TIM3 on leukemic stem cells in comparison to those who achieved remission (64.18 ± 20.95 versus 38.55 ± 30.69. Disease-free survival was higher in those who had remission in comparison to those patients who failed to achieve remission (14 months versus 12 months). Conclusion: lower T-cell immunoglobulin mucin-3 expression may improve outcome and survival of patients with acute myeloid Leukemia but further large control study studies are recommended
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