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[9004224.] رقم البحث : 9004224 - |
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Nullifynig leakage of pancreaticojejunostomy after pancreaticoduodenectomy / |
| تخصص البحث : General |
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SECI Oncology Journal / / vol.8 - 30/6/2020 |
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تاريخ تقديم البحث 07/12/2020 |
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تاريخ قبول البحث 19/01/2021 |
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عدد صفحات البحث 5 |
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ندي طلعت فرغلي محمد |
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طارق حسانين عبد العزيز ابو النصر - مؤلف رئيسي |
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pancreaticodudenectomy, pancreaticojejunostomy, postoperative pancreatic fistula, pancreatic surgery. |
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Background: Pancreatic anastomosis is the corner stone of pancreaticoduodenectomy. Postoperative pancreatic
fistula is a major cause of morbidity and mortality. The optimal method of pancreatic remnant reconstruction is
controversial and no single technique has shown to be superior. The aim of this work was to present the results of a
novel technique for pancreaticojejuonostomy in 36 patients after pancreaticoduodenectomy
Method: Our anastomosis is a two layers anastomosis. First layer was done with interrupted transverse mattress
sutures with 4/0 PDS including the whole thickness of the pancreas and whole thickness of the jejunum (not duct to
mucosa only ). Sutures are taken over a 14 G stent inserted in the pancreatic duct and jejunum. A second interrupted
mattress sutures were taken between the seromuscular coat of the jejunal stump and the outer half thickness of the
pancreas |
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[9004225.] رقم البحث : 9004225 - |
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The role of PANE1 as a model for minor histocompatibility restricted antigen in hematopoietic stem cell transplantation for leukemic patients / |
| تخصص البحث : General |
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SECI Oncology Journal / / vol.8 - 30/6/2020 |
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تاريخ تقديم البحث 07/12/2020 |
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تاريخ قبول البحث 19/01/2021 |
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عدد صفحات البحث 6 |
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ندي طلعت فرغلي محمد |
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مها حسنى محمد حماد - مؤلف رئيسي |
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Stem cell transplantation; Leukemia; Minor Histocompatibility antigens; PANE1 |
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Background:
In hematopoietic stem cell transplantation (HSCT), minor histocompatibility antigens (MiHA) can be used as tools
for immunotherapy especially if they are restricted to hematopoietic cells like PANE1 MiHA.
Purpose of study:
We aimed at studying PANE1 as MiHA model in human leucocyte antigen (HLA) matched related Egyptian HSCT
patients regarding its frequency and the effect of mismatching in PANE1 on HSCT outcomes.
Methods:
Ninety-six patient/donor pairs were studied for the prevalence of disparities in PANE1 MiHA and its effect on graft
versus host disease (GvHD) and graft versus leukemia (GvL). A sequence- specific primer (SSP) approach was
used to determine the immunogenic (PANER
) and non-immunogenic (PANES) alleles of PANE1 gene. Student ttest,
Mann-Whitney U test, ANOVA F-test, and Kruskal-Wallis H tests were used to determine the significance of
the difference for quantitative data. Relations of qualitative data were determined using Chi-square test. Survival
analysis was done using Kaplan-Meier method to determine overall survival (OS).
Results:
High prevalence PANER
allele of PANE1 was observed in both patients and donors (192/192,100% of 96
patient/donor pairs). Mismatches in PANE1 gene were observed in 9 patient /donor pairs. Nine cases showed
relapse post-transplantation and there was no association between PANE1 mismatch and relapse (p=0.8).
Conclusion:
No association between mismatches in PANE1 gene and any transplant - related outcome was
observed. Which might decrease its use as a target for immunotherapy in Egyptian leukemia
patients. |
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[9004226.] رقم البحث : 9004226 - |
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Long-term outcomes after robotic minimally invasive esophagectomy for esophageal squamous cell carcinoma / |
| تخصص البحث : General |
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SECI Oncology Journal / / vol.8 - 30/6/2020 |
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تاريخ تقديم البحث 07/12/2020 |
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تاريخ قبول البحث 19/01/2021 |
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عدد صفحات البحث 7 |
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ندي طلعت فرغلي محمد |
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محمد حسين مهران شحاته - مؤلف رئيسي |
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Esophagectomy, minimally invasive surgery, robotic surgical procedures, recurrence and survival. |
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Background: The use of the minimally invasive surgery robotic esophagectomy (RE) for esophageal cancer (EC)
has been increasing over the past decade, as it reduces morbidity and mortality compared with other surgical
approaches. However, although the technical feasibility and safety of RE for EC have been reported, few studies have
evaluated oncological outcomes. This retrospective cohort study aimed to determine the long-term outcomes of RE
for EC.
Methods: Twenty-four consecutive patients who underwent RE with total mediastinal lymph node dissection for EC
between 2009 and 2013 were enrolled in this study. The short- and long- term outcomes, including the 5-year overall
survival (5yOS) and 5-year recurrence-free survival (5yRFS) rates, were examined retrospectively.
Results: With a median follow-up of 37 months, the 5yOS was 70.8% and the 5yRFS was 62.5%. Tumor recurrence
was found in nine (37.5%) patients, and liver metastasis, the most common site of recurrence, was seen in five (20.8%)
patients. Multivariate analysis demonstrated that pathological tumor stage (pT ? 2) and certain late complications of
surgery as measured by the Clavien–Dindo (CD) classification (pneumonia CD grade II and stenosis CD grade III)
were significantly associated with 5yOS, while pT ? 2 and pN ? 1 were significantly associated with 5yRFS.
Anastomotic leakage was the most common complication, observed in seven (29.2%) patients. The median number
of harvested lymph nodes was 41 and 13 patients (54.2%) had node-positive disease.
Conclusions: We have shown that RE for EC is not only safe and feasible but also has encouraging oncological
outcomes. We also demonstrated that late complications are significantly associated with long-term survival.
Confirmation in a prospective study would assure the place of RE in the management of EC with curative intent. |
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[9004227.] رقم البحث : 9004227 - |
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Expression of Estrogen receptor beta in Squamous cell carcinoma of bladder cancer / |
| تخصص البحث : General |
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SECI Oncology Journal / / vol.8 - 30/6/2020 |
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تاريخ تقديم البحث 07/12/2020 |
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تاريخ قبول البحث 19/01/2021 |
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عدد صفحات البحث 5 |
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ندي طلعت فرغلي محمد |
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رحاب حسن احمد - مؤلف رئيسي |
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Estrogen receptor beta, bladder cancer, squamous cell carcinoma, clinicopathological factors. |
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Background: bladder cancer is a major oncological problem; it has a high incidence rate with high mortality. Two
pathological types are detected in bladder cancer: urothelial and non-urothelial. In Egypt; it was the first common
malignancy in males but now it is the second after hepatocellular carcinoma, with the highest mortality worldwide.
The two main histopathological types in Egypt are transitional cell carcinoma and squamous cell carcinoma.
Treatment of bladder cancer has limited options and poor response. 5-year survival in metastatic bladder cancer is
5%. Studies are ongoing trying to find a new drug that can improve disease outcomes. Our study evaluates the
expression of Estrogen receptor Beta in bladder cancer and study the association with the clinicopatological factors. |
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