الفهرس 
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Abstract
Cu-IUDs are the most commonly used for long-acting, reversible contraception. The most common adverse effect associated with Cu-IUD use is AUB.
The uterine artery Doppler indices (RI and PI) were widely investigated to identify uterine hemodynamic changes in patients with IUCD-induced bleeding.
Tranexamic acid is an effective non-hormonal treatment that decreases menstrual blood loss in cases of heavy menstrual bleeding.
This study aimed to compare both uterine arteries’ Doppler indices Before and After the use of tranexamic acid to determine its effect on decreasing bleeding in women suffering from Copper IUD-induced abnormal uterine bleeding.
This was a cross-sectional one-arm clinical trial conducted over 6 months at Ain Shams University, Maternity Hospital. The study included 30 women who were suffering from Copper IUD-induced AUB and presented at the Gynaecology clinics of the Maternity Hospital of Ain Shams University. After a baseline Doppler ultrasound, all 30 women received tablets containing 500 mg of tranexamic acid at the beginning of the cycle. The recommended dose is 2 tablets 3 times daily for 4 days. Again, transvaginal ultrasound and Doppler blood flow assessment of the uterine arteries were performed after treatment on the beginning of menstrual days (days 2-4 of the menstrual cycle) and any cycle after 3 months of Copper IUD insertion to avoid insertion-related bleeding.
The age ranged between 25 to 35 years with a mean ± SD of 30.5 ± 3.3 years. The BMI ranged between 20.19 to 28.95 Kg/m2 with a mean ± SD of 25.2 ± 2.2 Kg/m2.
The right uterine artery PI before taking the drug ranged between 1.83 to 2.94 with a mean ± SD of 2.3 ± 0.3 while after taking the drug ranged between 1.58 to 2.99 with a mean ± SD of 2.1 ± 0.3. There was a highly statistically significant difference before and after taking drugs as a regard Right PI at (p<0.0001).
The right RI before taking the drug ranged between 0.78 to 0.97 with a mean ± SD of 0.8 ± 0.0 while after taking the drug ranged between 0.69 to 0.87 with a mean ± SD of 0.8 ± 0.0. There was a highly statistically significant difference before and after taking drugs as regards Right RI at (p<0.0001).
The left PI before taking the drug ranged between 1.84 to 2.9 with a mean ± SD of 2.3 ± 0.3 while after taking the drug ranged between 1.54 to 2.56 a with a mean ± SD of 2 ± 0.3. There was a highly statistically significant difference before and after taking drugs as regard left PI at (p<0.0001).
The left RI before taking the drug ranged between 0.77 to 0.97 with a mean ± SD of 0.9 ± 0.0 while after taking the drug ranged between 0.64 to 0.88 with a mean ± SD of 2 ± 0.3. There was a highly statistically significant difference before and after taking drugs as regard left RI at (p<0.0001).
As regards patient satisfaction, the majority of patients (40.0%) gave a rating of 9, followed closely by a rating of 10 (33.3%). A smaller percentage of patients gave a rating of 8 (23.3%), and the lowest rating of 7 was given by (3.3%).