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Abstract
To study the effect of normalized FSH / LH ratio in PCOS patients via the use of a short pre treatment course of OCP on the success of ovulation induction and pregnancy rate. Kasr Alaini hospital. Retrospective observational comparative study. This study has been conducted on 150 patients attended the infertility outpatient clinic of obstetrics and gynecology department Faculty of medicine - Cairo university from November 2014 till June 2015. Patients were divided into two groups; group 1 induction by CC and/ or HMG with pre treatment OCP, group 2 CC and / or HMG without OCP pretreatment. We found: The No. of mature follicles ( mean): in group 1 is 2.91, while in group 2 is 1.25. The p value > 0.001 indicate highly significant difference in the ovulation outcome. The pregnancy rate: pregnancy test were done in 117 / 150 cases Only 32 cases had positive pregnancy test and 85 had negative pregnancy test. group 1 22 cases got pregnant, while in group 2 only 10 cases got pregnant. The p value > 0.041 indicate that there is a significant difference between the pregnancy rates in both groups. Cancelled cycles: after the stimulation protocols 21.3% of cases were cancelled; in group 1 were 7 cases ( 9.5%) of patients, and group 2 were 25 (32.9%), more cancelled cycles in group 2 than group 1. Hormonal profile: LH mean decreased after using the OCP from 10.539 to 5.363. As well the FSH / LH ratio mean increased after OCP from 0.533 to 1.067 which towards normalized ratio