الفهرس 
AcknowledgementOnly 14 pages are availabe for public view
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Abstract
A- In-Vitro Interaction of Tested Insecticides With Plasma Enzyme Activity in Various Blood Group Samples: The following insecticides were tested for their inter action with the pla~ma enzyme in-vitro activity of the blood group samples A, B, AB and 0:- profenofos, fenitrothion, ma lathion, methomyl, permethrin and Cypermethrin. The monitored enzymes were cholinesterase, (ChE), monoamine oxidase (MAO), alkaline phosphatase (AP), glutamic pyruvic transaminase (GPT) , glutamic oxaloacetic transaminase (GOT), creatine phosphokinase (CPK), pyruvate,kinase (PK), lactate dehydrogenase (LDH), and glucose -6 Phosphate dehydrogenase (G-6PD). The insecticides were tested as alcoholic solutions in the two concentrations lXIO-4M, and IXIO-~, to simulate the acute toxic level and the sublethal level respectively. ChE was slightly affected even at the higher concentrations. The degree of inhibition of ChE varied according to the type of blood group. On the con trary MAO was activated slightly. In the case of profenofos, feni trothion, malathion and methomyl, AP, GPT, GOT, PK, and LDH were inhibited by different magnitudes depending upon the type of blood group or insecticide and its concentration. The enzymes CPK, and G-6PD showed induction all the time. With permethrin and cypermethrin, AP and GOT were also induced in their activity, while the other enzyme behaved the s~e as with other compounds. In the general trands but with .specific effects. B- Variation in Blood Biochemical Constituents in Different Blood Groups: The base line for the biochemical constituents content in the different blood g~oup samples was investigated. Var iations in the levels of the 13 biochemical parameters were obvious between the four blood groups. Generally blood gro up 0 got the lowest level in the total phospholipids. and phosphatides, while the same group showed the highest level in TG’, B-lipoprotein, cholesterol., total lipids, total pro tein, and total phosphorus. On the other hand, blood group A showe d the lowest level in TG” B-lipoprotein, Cholesterol, total lipids, and total protein, while the same group had the , highest level in total phospholipids, phosphatides, copper, iron, and calcium. These clear variations were found statis ticallysignificant. Thus these were differentiations between ’the blood groups in the specific biochemical constituents. Such specific differneces should lead to variations in the response towards the toxication of insecticides and other toxicants. c- Variation in The Plasma Enzvmes Specific Activities in Diff erent Blood Group Samples: The base line of specific activity of the monitored nine enzymes in the untreated control samples of different blood groups, was carried out according to the standard methods. Group B was characterised by having the minimum specific ac tivity of seven of the nine compared enzymes. Blood groups A and 0 were superior in the specific activity of an apperi cable number of the included enzymes. Such basic specific differences in the base line enzyme specific adtivities would suggest the differences in the human susceptibility to toxi cants as it was proved to vary towards diseases. D- In-Vivo Interactions of the Tested Insecticides With Plasma Enzyme Activities In Various Blood Group Individuals: For every compound of the in-Vivo five tested insectici - des four individuals each of different blood group were exposed to the field application of that compound. From the exposed individuals, blood samples were taken after 24 hrs, 30 days and 180 days after exposure. The tested insecticides in these in vivo study were: profenofos, fenitrothion, malathion, methomyl and cypermethrin. The nine selected enzymes were monitored for their relative activity after such periods of exposure. The obtained values were statistically analyzed by the T test. Significant differences were recorded especially during the 24 hrs., and 30 days samples. Specific variations support the hypothesis of the role of blood group specificity in biologi cal responses. E- In-Vivo Interaction of the Tested Insecticides With the Plasma Biochemical Constituents Content in Various Blood Group Samples: The same blood samples from the different blood group individuals were also used to monitor the levels of biochemi cal constituents in the various blood group types after the three intervals after exposure. Again the recorded values were statistically analyzed by the T test. Significant dif ferences were shown in many of the critical and essential parameters taken in consideration. Such variations implies justifiable differences in the biological response of human subjects of different blood groups. ^leng