الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
 |  | from | 169 |  |  |
| | | from | 169 | | |
Abstract
Much experimental evidence .supported by epidcmiologic observ.ilions in humans points It) Ilic invasive stage of the parasite i.e. schislosomulum as the main target of immunity whereas the adull worm seems relatively unaffected by immune eflcctoT mechanisms (Smilhers & Terry, 1967). Schistosomal inteclion eticil.s a very intense humoral re.s|5onsc amony which iti.i.s.sjve ptodm-’tioti of fvllikilli(Rous.wiux’Prcvwl ct On the other hand, cytoloxic T-ceH.s are not involved mainly in killing mechanisms but it is [Jie antibody dependent cell mediated cytotoxicity (ADCC) which carry on (lie main defence against infection which does in( involve (lie conventional lymphoid cells but rallier the pha^ocylic cells including eo.sinophils and macrophayes in.
iddition to plaleJels (Capron et aL, 1980.). The reiative inefficiency of tlie.se killing processes and the lack of long Li.sling immunity in chronic infection might be explained by the presence of blocking antibodies to ADCC and in particular 1^04 and IgG^ (Bigitta et al., IW8). The production of these inlibodie.s is related to interplay between cells,