الفهرس | Only 14 pages are availabe for public view |
Abstract The aim of this investigation was to study the prophylactic and therapeutic effects of potassium administration on blood pressure level, serum and urine sodium and potassium levels, fasting serum lipids and HDL / total cholesterol ratio in hypertensive rats. The present investigation was performed on 48 adult male albino rats. Rats were divided into 4 main groups: I- Normotensive control group. II- Non-treated hypertensive group. III- Concomitant potassium-treated hypertensive group. IV- Post-treated hypertensive group: • IV-a : Potassium post-treated hypertensive group. • IV-b . A CE-I post-treated hypertensive group. • IV-c: Combined potassium and ACE-I post-treated hypertensive group. The results showed that the induction of DOCA-salt hypertension resulted in a significant elevation in SBP, DBP and MABP. It also resulted in a significant increase in serum sodium and urine potassium, and a significant decrease in serum potassium and urine sodium levels. Fasting serum total cholesterol, LDL and triglycerides levels were significantly increased, while, fisting serum HDL and HDL/total cholesterol ratio were significantly decreased. These results were in comparison with the corresponding values in normotensive control group. |