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Abstract
Successful pain management requires that adequate analgesia is achieved without excessive adverse effects. Perioperative analgesia has traditionally been provided by opioid analgesics,however, extensive use of opioids is associated with a variety of perioperative side effects. Therefore, anesthesiologists and surgeons are increasingly turning to nonopioid analgesic techniques as adjuvants for managing pain during the perioperative period to minimize the adverse effects of analgesic medications. The aim of this study is to compare the analgesic efficacy, sedative effect and safety profile of dexmedetomidine with that of the potent analgesics morphine and tramadol in the early postoperative period following major abdominal surgeries. This study was carried out on 45 ASA I & II patients admitted to Menoufyia university hospital for major abdominal surgery.