الفهرس 
Diabetes mellitusOnly 14 pages are availabe for public view
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Abstract
Insulin dependent diabetes mellitus (IDDM) may result from many causes. Autoimmune disorders are one of the most important and commonest causes of IDDM. Autoimmune diseases appear as a major complications of immune dysregulation, based on the detection of several cytokines in the sera of patients with IDDM.Interlekin-6 (IL-6) is one of these cytokines, which can play an important role in induction of autoimmunity as well as involved in inflammatory reactions observed in insulin-dependent autoimmune diabetes mellitus. At the same time, IL-6 perhaps by increasing the generation of cytotoxic T cells, may play an important role in pathogenesis of IDDM.On the other hand, non- Insulin dependent diabetes mellitus (NIDDM) is associated with increased blood concentrations of markers of the acute phase response and IL-6 is the main cytokine mediator for this response. IL-6 mediated acute phase reaction in NIDDM is part of wide-ranging immune response.Also this work deails to determine serum Interlekin-6 (IL-6) concentrations in diabetic patients(Insulin dependent and non- Insulin dependent) and to evaluate its role in the pathogenesisand biochemical features for those patients .