الفهرس 
Epidemiology and EtiologyOnly 14 pages are availabe for public view
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Abstract
Thirty two patients with malignant hepatic focal lesions were treated with Radiofrequencv Thermal Ablation (RFA), in a multi- center prospective nonrandomized study that was performed in the National Liver Institute, Menoufiya University, Egypt and other hospitals in Boston, USA, with the aim of evaluating EFA as a locally ablative treatment modality for malignant hepatic focal lesions,
RFA was performed through different approaches, using different RF devices, either alone, or combined with surgical resection. All the patients were followed for one year. 27 (84.37%) patients showed evidence of complete tumor ablation on follow up CT scans, 24 (75%) of them after the first session. 11 (34.4%) patients developed complications. 6 patients (18.75%) developed local recurrences. The overall survival was 75% and the disease-free survival 50% at the encl of one year. The treatment-related mortality was 3.1%.
The lesion size was found to be the single most important factor that has a statistically significant relation to the outcome of treatment in terms of complete ablation, tumor recurrence and survival Though statistically insignificant, the results of the operatively performed RFA were superior to the percutaneous approach. No statistically significant differences were found between the different centers involved in this study or the different RFA devices.
from this stuclv it can be concluded that Radiofrequency Ablation is an effective and a relatively safe locally ablative treatment modality for local control of malignant hepatic focal lesions. It is easy to be performed through any of the three different approaches; the percutaneous, the laparoscopic, and the open surgery, and it can be repeated when necessary. Though inferior to the reported results of surgical resection, the results of UFA are yet comparable to surgery and even better than the reported results of Percutaneous Ethanol Injection (PEI) and other locally ablative therapies.