الفهرس 
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Abstract
Spontaneous ascilic lluicl infection (SAFI) is a frequent and serious complication in patients with chronic liver disease and ascites. However, the mortality rate has declined during the last decade due to the diagnostic and therapeutic improvement (Rimola et al., 2000).
The present study was designed to investigate the prevalence of aerobic and anaerobic infection in the ascitic fluid of chronic liver disease patients.
In this work, 50 patients with chronic liver disease and ascites were
studied. They were divided into group I and group II according to ascitic
fluid analysis. j
• Group I: included 25 chronic liver disease patients with proved
ascitic fluid infection.
• Group II: included 25 chronic liver disease patients with no ascitic
fluid infection.
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All studied patients were subjected to lull history taking, thorough clinical examination, laboratory investigations and ultrasound
examination.
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By comparing the most important clinical data, abdominal pain, fever and cnccphalopathy have been found to be a prominent clinical feature in group I with significant difference compared to group II.
There were no significant differences regarding liver function tests between the two groups.
However, as regarding the risk factors for the development of SAFI in our study, it was found that 56% of patients in group I were having previous history of sclerotherapy in contrast to 16% of patients only in group II, also there was significant difference between the two groups regarding the history of upper GIT bleeding.
Still the white cell count remains the golden test for diagnosis of ascitic fluid infection. In that study, WBCs count ranged between 500 - 3400/mm* and PMN count ranged between 250-3200/mm3 in group I, while WBCs count ranged between 100 - 400/mm3 and PMN count ranged between 90- 240/mm:’ in group II. In addition there is a significant decrease in ascitic fluid total protein and albumin levels in group I compared to group II which predisposes to group I infection.
Concerning results of bacterial culture in patients with SAFI in this study, culture positive cases constituted 5 (20%) cases out of the studied 25 cases.60% of the identified microorganisms were Ij. coli while 40% of them were streptococci with no anaerobic organisms detected.
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Regarding the results of antibiotic sensitivity tests: 100% of ascitic fluid cultures showed sensitivity to cefotaxime and cefoperazone and ceftrazidine while 80% were sensitive to ceftriaxone, ofloxacin, ciprofloxacin and amoxicillin/flucloxacillin 40% were sensitive to sulperazone and none were sensitive to amoxicillin / clavulanic acid, ampicillin/ sulbactam, vancomycin, cefepime, azatam, imipenam, amikacin, tobramycin, erythromycin, clarithromycin and azithromycin.