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Abstract
Periodontal diseases are multifactorial inflammatory diseases initiated by microbial and other environmental factors. Genetic factors are strongly proposed to control susceptibility and severity of periodontitis. In contrast to the simple monogenetic diseases, complex genetic diseases are not due to a single gene defect. In complex diseases, like periodontitis, genetic variants at multiple gene loci contribute to overall disease liability .Genetic polymorphism is the presence of several alleles (different forms) of a gene in a percentage of more than 1% for the rare allele in a given population. Association studies are concerned with the influence of the statistical association of genetic alleles with some diseases. Vitamin D receptor (VDR) gene polymorphism has been associated with diseases of bone loss and decreased bone mineral density (BMD) such as osteoporosis. Taq I VDR gene polymorphism has been reported to be associated with periodontal diseases where bone loss is a cardinal sign. This study is interested in the association of Taq I VDR gene polymorphism with AgP. Venous blood samples were collected from 20 patients with AgP and 20 healthy subjects for the control group. 8 patients out of the 20 had localized aggressive periodontitis (LAP), and the remaining 12 had generalized aggressive periodontitis (GAP).