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Abstract
Helicobacter pylori produces a chronic gastric infection that is widespread in the human population and is associated with severe disease sequelae including gastritis, peptic ulcers, mucoa-associated lymphoid tissue lymphoma, and gastric adenocarcinoma.
Dendritic cells are potent antigen-presenting cells that are present in the gastrointestinal tract and are required for the induction of a Th1 T-cell acquired immune response. Since infection with the gastric pathogen Helicobacter pylori elicits a Th1 cell response, the interaction of these organisms with dendritic cells induces its maturation & activation leading to Th1 response.
The aim of the study was to assess circulating mature CD +ve dendritic cell in patients with Helicobacter pylori related gastritis
This study had been carried out on 40 patients Those patients were admitted or followed up in Ain Shams University Hospitals, Clinical Gastroenterology and endoscopy units.
Group I:
Included 20 patients with gastritis associated with helicobacter pylori infection.
Group II:
Included 20 patients with gastritis not associated with helicobacter pylori infection.