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Abstract
The excimer laser are a group of lasers that have found wide applications in a variety of medical fields including dermatology, cardiology, ophthalmology and orthopedics. The excimer laser is of particular interest to dermatology is the 308 nm xenon chloride.
The mechanism of action of excimer laser in Psoriasis is due to its apoptosis action. Also its apoptosis action is involved in treatment of Alopecia Areata, Mycosis Fungoides Oral Lichen Planus, Acne Vulgaris and Atopic Dermatitis. It was proved to be the strongest apoptosis inducer, while in vitiligo and hypopigmented lesions it causes an increase melanogenesis and melanocyte stimulating hormone.
Patients require 18-30 sessions for complete clearing. The intensity varies according to skin type. Determination of MED is very important as dose is calculated in terms of it. Exposure to UV light is early in the treatment cycle and then gradually increases over time.
It was subsequently demonstrated that these laser could precisely ablate surface of variety of tissues with almost no detectable thermal effect below ablated surface which was termed ”Cold Ablation”.
Excimer laser has a variety of applications in dermatology such as Psoriasis, Vitiligo, Alopecia Areata, Hypo-pigmented Lesions, Mycosis Fungoides, Oral lichen planus, Acne Vulgaris, Perioral Dermatitis and Atopic Dermatitis.