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Abstract Excessive vasospasm leading to a permanent elevation of the blood pressure is a common phenomenon in civilized man. whereas there are many factors in the genesis of hypertension emotional, psychosomatic, nervous, endocrine, and renal – there is one common denominator in most cases, and that is altered arterial reactivity. Successful treatment of hypertension is accomplished by two types of chemical agents , one which acts on nerves and the other on blood vessels . The latter group are all chelating agents , completing metals : hydralazine , EDTA , thiocyanate , nitroprusside , aside and the like . Thus it appears that a metal is somehow involved in hypertension. |