الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 74 |  |  |
| | | from | 74 | | |
Abstract
This work aims to synthe ize ome new quinazoline derivati es
and to rudy their biological activity. It in olves synthesis and reaction
of 4-(2-meth 1-4-oxo-4H-quiuazolin- ~- lj-benzoie acid 1, ia the reaction
of benzoxazinooe \. ith p-amino benzoic acid afforded l. Ethyl est r of
the latter. 4-(2-111ethyl-4-o.• -4H-quinllzol:in-3- Ijbenzoic acid eth I e tel
2, wa reacted with hydraziue hydrate to give the corr .pouding 4-(2-
methyl-a-ox -4H-ql1il111Zo1in-” ljbenzoic Acid 11drazide 3 which in tumreacted with active methylene compounds namely acetyl acetone and
ethyl acet acetate to give pyrazole derivative, 3.[4.”:- .diruethyl,
pyrazole-Lcarbon l)phenyl]-2-meth 1-”H-quinazolin-4-one /I and 2-
methyl-J-] 4-(3-methy[.:).oxoA,: -dihj dro-pyrazole-l-carbonyl -phenyl].
3H-quinazolinA-one 5 re pecrively. Al o, hydrazide 3 wa reacted with 3-nillobenzflldehyde to give chiff base 6 and with ammonium thioc anate to give 3-methyl-3-[L1-(5-thioxo-4.- -dihydro-l Hs] 1.2,4[niazol-J -ylj-pheuylj-J Hsquinazolin-so the other hend iutrcducrion 0 is rhioc ’alllate to acid tevabled us to e tablish heterocyclic ystems of remarkable biological activity. The . llcidchloride f acid 1 t a react ’\ ith emmorunm
thiocyanate and gave a i othiocyanate derivative 4-(2-methyl-4-oxo-4Hquinaz line ylj-benz 1 i othiocyenaie 8. which \ a reacted \ ith
nitrogen nucleophile such a ’ phenyl hydraziue, glycine, anthranilic acid
and o-aminophenol to give the corresponding triazolenucleu , ”1,3-
oxazole, quinazoline and benzoxazole, Thus 2-methyl-’” -[4-(2-phenyl-5-thioxo-[ 1,2 4]trillzolidin- -yll-pbenyl]- 3H-quimrmJinA-one to, -(2-)l)e(capto-5-oxo~oxazolidill.2-yl)-4.(2- meth l-4-oxo-4H-quinazolin-3-yl)benzamide 11. 2-methylphenyl]-3Hquinazolin- e-one 13, -benzo-oxazol-_- .•I--4-(2-m thyl-4-oxo-4Hquinazolin-ylj-benzamide 15 re P ctively.