الفهرس 
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Abstract
The aim of this study WU3 to investigate, the toxicological effects of aflatoxins on male albino rats and the role of ’vltamins supplementation to overcome the toxicological effects of aflatoxins (AFT) in male rats. The results revealed that: 1- Results revealed that rats fed on AFT-contaminated diet showed decrease in liver and body weight, while kidney weight were increased in AFT treated group as compared with control group. The aflatoxin decreased growth rate, feed intake and feed efficiency. 2- Aflatoxin increased the glucose level and decreased the cholesterol level in blood, Activities of blood alanine aminotransferase (AL T) and aspartate aminotransferase (AST) were increased by aflatoxin, however, the glutathione peroxidase (GSH-Px) activity in the blood vas decreased by aflatoxin, 3- Histopathological study revealed severe degenerative and necrotic changes in liver and kidney. 4- In vitamins supplemented group: The results showed that increase in tile body weight was recorded in groups supplemented with vitamins A, ~-corotene and E, and increase in liver weight after supplementation with vitamin E was recorded. • The kidney weights of rats treated with vitamin A, ~-corrotene and vitamin C showed. a decrease. • ALP activity was decreased in e-carotene, vitamin C and vitamin E, supplemented groups. • ALT activity was decreased in ElI1 vitamins supplemented rats. • AST activity was decreased in ~-caroa.tene groups, • BUN (blood urea nitrogen) was decreased with p-caroten~ treatment compared with AFT treated group, • Supplementatlon with vitamins improved the growth rate and significantly decreased the activities of ALP and ALT particularly after treatment with vitamins ~•catotene. C and E. The severity of pathological changes was relatively less in all vitamins supplemented groups. • Vitamins supplementation reduced the toxicity of aflatoxins nthrough partially correcting and improving the biochemical nparameters and histopathological changes. • The study showed several degenerative and necrotic changes in liver and kidney. nLiver: • The results showed that, degeneration of hepatic cells and diffused fatty change scattered allover the hepatic parenchyma. Kidney: • The results sho ••~••d that dilatation and congestion of renal blood vessels associated with interstitial hemorrhage in between the renal tubules In addition to perivascular round cell aggregation.