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Abstract
Diabetic nephropathy (DN) is a serious complication of diabetes mellitus (DM). Though the progression of DN is very slow, many of diabetic patients develop ESRD. Chronic hyperglycemia is considered as the major initiator of diabetic kidney disease, either by creation of oxidative stress or by induction of growth factors and cytokines. Moreover, diabetic dyslipidemia plays an important role in the progression of DN.
The present study was undertaken to assess whether lipid profile, malondialdehyde (MDA), transforming growth factor-beta 1 (TGF-β1) and angiotensin II (Ang-II) levels in type 2 diabetic patients are associated with diabetic kidney disease as reflected by their albumin excretion rate (AER).
In order to fulfill our aim in this study, it was conducted on 70 subjects divided into four groups: group I: consists of 16 healthy volunteers served as control group, group II: consists of 14 diabetic patients with normoalbuminuria.