الفهرس Only 14 pages are availabe for public view
 |  | from | 286 |  |  |
| | | from | 286 | | |
Abstract
Present work aimed mainly to:
1. Study some factors dealing with induced hyperlipemia and in experimental atherosclerosis in experimental rats. This is done through long term supplementation of diet enriched with saturated fats and cholesterol then followed by alloxan administration.
2. Reflection of this on certain changes recorded for selected biochemical parameters in blood and aortic tissues. This was followed by histopathological studies for aorta using different stains. The study included two parts.
Results
1- Rats received hypercholesterolemic diet followed by alloxan injection demonstrated significant increase in glucose, lipid profile (TC, TAG, LDL), susceptibility of non-HDL-C to oxidation, atherogenic indexes (TC/HDL, LDL/HDL), inflammatory markers (CRP), chemokine expression. Moreover significant decrease was demonstrated in NO and aortic antioxidant content (GSH and SOD).
2- Histopathological examination revealed massive cellular infiltration, foam cell formation, and marked distribution of glycosaminoglycans allover the aortic layers. Increased collagen synthesis and degradation joined with loss of elastic fibers corrugation was also observed.
In conclusion the present study demonstrated that dietary fatty acid types greatly affect the lipoprotein oxidation susceptibility as well as endothelial expression of chemokines associated with development of atherosclerosis. Although n-3PUFA (FO) have the most powerful anti-inflammatory activity, MUFA (OO) which combines both potent antioxidant and moderate anti-inflammatory properties is highly effective in reducing of aortic atherosclerotic lesion than n-3 and / or n-6 PUFAs supplemented diets. This study shows that catechin cotreatment with enalapril has more prominent and significant effect on reduction of lipid profile, oxidative stress and subsequent improvement of endothelial dysfunction and attenuation of chemokine release as compared to enalapril treatment alone. These findings are supported by positive correlations between MCP-1, RANTES from one side, LDL/HDL and OX-LDL from the other side (0.71, 0.79, P<0.001 and 0.82, 0.80, P<0.001) respectively. While negative correlation with NO (-0.69, -0.90) was observed