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Abstract Affective syndrome associated with cerebrovascular diseases represent an important area for research, although many of the clinical characteristics have been reported in the literatures for years, still more research and studies should be undertaken, and several studies have now demonstrated that post stroke depression is a frequent sequel of cerebrovascular diseases with incidence about 30 - 50%, and that the anterior lesions, particularly those involving the left frontal cortex and left basal ganglia are strongly associated with major depression. The aim of this work was to determine the prevalence of depression after cerebrovascular accidents, its possible different etiological factors include age, sex, marital status, educational level, history of smoking or other drug or alcohol abuse, premorbid personality, past psychiatric history, family history of psychiatric disorder, lesion location, degree of weakness with the type of depression. And that in both Egyptian sample of patients as well as a Saudi sample of patients. 167 For this study each patient was subjected to:- 1- Full neurological assessment. 2- Full psychiatric sheet and examination using the DMS III R criteria for diagnosis of the psychiatric illness 3- Brain CT Sean to confirm the neurological diagnosis and to detect the site of the lesion. 4- Beck Depression Inventory Scale (BDI) and Hamilton Rating Scale for Depression (HAMD) to measure the degree of depression. 5- Social and Occupational ’”Function Examination Scale (SOFAS): to assess the social and occupational function. 6- Mini Mental State Examination: to assess the cognitive and intellectual impairment. Our study showed that the total prevalence of depressive illness in the experimental group is 40%, 36% in the Egyptian group and 44% in the Saudi group. No significant differences showed between the Egyptian group and Saudi group. Also in the total of the experimental group, there was a significant correlation between major depression after cerebrovascular stroke and the degree of physical disability, lesion location, the progressive course 168 of the neurological and psychiatric illness low scores of Mini Mental State Examination, introvert premorbid personality and a positive family history of psychiatric disorders, and a personal past history of psychiatric illness There were no significant correlation with other parameters. The time interval between the incidence of stroke and appearance of a depressive disorder (in months) was 2.12 for minor depression and 0.906 for major depression. We concluded that post stroke depression may be a multifactorial in etiology (lesion location, severity of physical disability, intellectual impairment, or genetic loading ofpsycbiatric illness). We recommended that psychiatric examination is an important and essential part in the examination of stroke patients for psychiatric sequale of stroke and starting the suitable rehabilitation programs. Early diagnosis of post stroke depression is very important for the rapid recovery and good prognosis of such patients. |