الفهرس 
Idiopathic thrombocytopenic purpuraOnly 14 pages are availabe for public view
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Abstract
The high incidence of ITP cases urged us to study the pathogenesis of this disease specially the role of T cell eo-stimulatory molecules, which considered the most important pathway in the pathogenesis of the disease in many past studies that looked at the blockade of this pathway as a promising control of the disease.
Our study included 80 subjects divided into 3 groups as follow:
Group 1:Patients of acute ITP (26 cases, 14 males and 12 females), their age ranged from 2.5-12 years.
Group 2:Patients of chronic ITP (34 cases, 12 males and 22 females), their ages ranged from 2-18 years.
Group 3: Twenty age and sex matching healthy subjects were served as controls from children attending the hospitals included in the study for evaluating their general condition after permission from their parents.
All patients were under treatment with steroids and/or anti-D immunoglobulins, except four from the chronic ITP group, were not under treatment. Four of the chronic ITP group were splenectomized.