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Abstract Phrimidines and their dervatives have stimulated interesting research in biology and medicine due to their antiparkinsonian antitumor antimicrrobial and antiinflammatory activies propeties they have been shown to exert pronounced physiological effects the replacement of naturally occurring pyrimidine bases of the dna of microorganisms by unnatural analogous pyrimidines is attributed to the similarity in their steric properties and the tautomeric behaviour beside prton mobility in the pyrimidines since hydrogen bonding between purine pyrimidine bases is of the utmost importance for maintenance of the physiologically active helical structure of the dna molecula. |