الفهرس 
Material and MethodsOnly 14 pages are availabe for public view
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Abstract
A total number of CO cases whose ages ranging from 12 years to 60 years, were carefully selected from the attendants of inpatients of the diabetic clinic of Kaser-El-Aini hospital and the DiabetiC institute. These included 20, apparently healthy subjects (10 males and 10 females) as a reference group, 20 insulin dependent diabetes mellitus (10 males and 10 females) and 20 non-insulin dependent diabetes mellitus (10 males and 10
females).
All the cases were carefully subjected to clinical and laboratory examinations to confirm the diagnosis and to assess the degree of kidney impairment.
The plasma protein profile revealed that in NIDDM there was a significant decrease in serum albumin and IgG, while there was a significant increase in B2 microglobulin. Also there was no significant change in the serum transferrin. In IDDM, there was no significant change in serum albumin, transferrin, IgG and C2
microglobulin.
Urinary protein profile proved that albumin could be
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detected, in most of the cases of both IDDM and NIDDM.
Selective permeability studies showed that one IDDM case had highly selective permeability, two cases showed moderate selective permeability and two cases showed poor selective permeability, while in NIDDM, two cases showed poor selective
permeability.
from our study, we could conclude that microalbuminuria and IgG uric of diabetes were glomerulus in origin and were associated with a normal tubular function, as supported by the finding of normal excretion of 32 microglubulin.
Therefore, we recommended that in diabetic patients with nephropathy kidney function profile should be indicated. Albumin clearance could be used as a laboratory follow up parameter in diabetic patients for any pathological lesion in the glomerulus. Also, the renal tubular function could be evaluated by estimating the urinary B2 microglobulin level which was a sensitive indicator of tubular reabsorptive capacity.