الفهرس 
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Abstract
This is a clinico-pathological, retrospective-prospective study of 236 consecutive and non-selected cases of breast carcinoma, in Kuwait, during the period from January, 1965 to the end of May, 1976 inclusive.
The cases were studied for the percentage of tumour cells containing female sex chromatin bodies ”sex chromatin counts”, histological typing and grading of the tumours according to the World Health Organization’s classifica-tion (1968), prognosis as shown by survival and recurrence-free interval, and response to hormonal therapy.
Our findings can be summarised as follows:-
1.Carcinoma of the breast showed sex chromatin counts different from those of the normal female tissues thus constituting an exception to the ”patient-tumour identity” rule.
2.No definite relationship could be demonstrated between the sex chromatin counts in the cells of the mammary
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carcinoma and the various histological types.
3.An inverse relationship could be demonstrated between the sex chromatin counts and the histological grades of the tumours; lower grades being associated with higher sex chromatin counts and vice versa. This means that simple sex chromatin count can be used for grading of a tumour and thus for prognosis.
4.There was a direct relationship between the sex chro-matin counts and the length of survival; higher counts (more than 15%) being associated with longer survival and vice versa.
It could be shown that low sex chromatin counts
(15% or less) were associated with higher recurrence rate and shorter recurrence-free interval.
5.Those patients with breast carcinomas having sex chromatin counts more than 15% responded to hormonal therapy better than those with counts of 15% or less. So this simple test of counting the percentage of nuclei with female sex chromatin bodies can be used to predict the responsiveness of the tumour to hormonal therapy instead of the other sophisticated laboratory methods, usually not available in developing countries.