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Abstract The present study was conducted on thirty premenopausal patients aged 32-46 years with a mean of 39.17 years, also the patients were subjected to simple abdominal hysterectomy with preservation of one or both ovaries. All patients were subjected to : [1] Thorough history taking. [2] Thorough general examination. [3] Thorough abdominal examination. [4] Local pelvic and gynecologic examination. [5] Vaginal pap smear, before, 3 months, and 6 months after hysterectomy. [6] Blood sample was taken for estimation of FSH and E2-level before, 3 months and 6 months following hysterectomy. [7] Follow up of cases was done 3 and 6 months following surgery. [8] Data were collected and fed into an IBM compatible computer and statistical analysis was performed. [9] Data were checked for accuracy. [10] Chi-square and analysis of variance was carried out according to Snedecor and Cohchran (1967). [11] Value means were compared by Duncan’s Multiple Range test (Duncan 1955). [12] All statistical analysis were performed using analysis of Summary and Conclusion - 123 - variance technique by means of MSTATC computer software package. The results of this study revealed the following finding: [1] There is no statistically significant change of FSH before and after operation either 3 or 6 months postoperatively. [2] There is no statistically significant change in E2-concentration before and after operation either 3 or 6 months postoperatively. [3] There’s is a statistically significant reduction in E2- concentration was found in the second day postoperatively. [4] There no statistical relationship between age and FSH-level before operation, but there’s a statistically significant relationship between advancement of age and FSH-level, three months and six months after hysterectomy. [5] There’s no statistical relationship between E2-level and age in all E2 measurements. [6] There’s no statistical relationship between parity and the change of hormonal level (FSH, E2) before or after hysterectomy. [7] There’s no statistical relationship between (weight and body mass index) and the change of FSH or E2 level before or after hysterectomy. [8] All vaginal smears taken three and six months after hysterectomy showed persistent Oestrogenic pattern denoting continued vaginal oestrogenic effecting. |