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Abstract Non-alcoholic fatty liver disease is a clinicopathological condition that comprises a wide spectrum of liver damage, ranging fiom siinple steatosis to steatohepatitis, advanced fibrosis and cirrllosis. Non-alcoholic steatohepatitis represents only a stage within the spectrim of nonalcoholic fatty liver disease and is defined patlologically by the presence of steatosis together with necro-inflammatory activity. The true prevalence of non-alcololic fatty liver disease is unknown, but it is estimated that it affects 10-24% of the general population in different countries and up to 25% to 75% in patients with obesity and type 11 diabetes mellitus. Hepatic steatosis has a benign clinical course. In contrast, non-alcololic steatohepatitis (NASH) may progress to cirrhosis and livesrelated death in 25% and 10% of patients, respectively. Cases occur nost comnonly in obese, middle-aged women with diabetes. |