الفهرس 
Review of LiteratureOnly 14 pages are availabe for public view
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Abstract
Forty renal patients as well as ten healthy volunteers were selected for this study.
The selected subjects were classified into the following groups.
-Grou I: Control group (comprises 10 volunteers, 5 females and 5 males)
-Groan II: 10 patients with end stage renal failure under dialysis
(4 females and 6 males).
-Grou III: 30 renal patients under conservative treatment (14
females and 16 males).
All patients were subjected to a thorough history taking and clinical examination with special stress on: -
0 Etiology and manifestation of renal failure.
Duration of disease and duration of dialysis.
0 Manifestations of atherosclerosis and recurrent infection.
The following laboratory tests were performed to every subject:
0 Complete blood picture Complete urine analysis.
0 Serum albumin, Serum urea, Serum creatinine and creatinine clearance.
0 Serum glutathione and glutathione reductase.
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Summary & conclubiu.•
Each patient was given an antioxidant therapy composed of vitamin A 30 (5.54mg/day), vitamin C (100mg/day) and vitamin E ( rag/day) for 6 months. The reevaluated and the laboratory investigation were reperformed after treatment.
The following were reported in our work: - -Antioxidant activity lutathione
as measured by glutathione and g
reductase was significantly lower in all renal patients when compared with controls.
-Glutathione and glutathione reductase was significantly lower in group 11 when compared with group
-Hemoglobin level, creatinine clearance and serum albumin were
red with controls.
significantly lower in all renal patients when comp
-Hemoglobin level, creatinine clearance and serum albumin were significantly lower in group 11 when compared with group 111.
was significantly higher in all
-Serum creatinine and serum urea renal patients when compared with controls.
-Serum creatinine and serum urea was significantly higher in group 11 when compared with group III.
-There was significant positive correlation between glutathione and
lobin level, serum albumin and creatinine glutathione reductase, hemog clearance.
-There was significant negative correlation between glutathione and serum creatinine, urea, and duration of disease, hypertension, infection and proteinuria.
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Summary & conclusion
-There was significant positive correlation between glutathione reductaseand hemoglobin level, serum albumin and creatinine clearance.
-There was significant negative correlation between glutathione reductase and serum creatinine, urea, and duration of disease, hypertension, infection and proteinuria.
Treatment with antioxidant for 6 month has the following effects: -
-Significant elevation in glutathione, glutathione reductase and hemoglobin level in group II (dialysis group).
-Significant elevation in glutathione, glutathione reductase creatinine clearance serum albumin and hemoglobin in group III (patients under conservative treatment).
-Significant reduction in serum creatinine and serum urea in group III.
Conclusion:
Our study clearly showed the beneficial effect of antioxidant therapy in improving the antioxidant status, reduction of complication and reduction of progression of renal impairment in all patients.