الفهرس 
PARAOXONASE ENZYMEOnly 14 pages are availabe for public view
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Abstract
Chronic renal failure (CRF) is a persistent and irreversible
reduction in the over all renal function. The common causes of CRF are
diabetic nephropathy, chronic pyelonephritis, obstructive uropathy and
chronic glomerulonephritis.
PON is a serum esterase synthesized in the liver. It is a Ca+2
dependant glycoprotein. It’s associated with ApoA-I on HDL-c through
hydrophobic region at its amino terminus.
PON is principally responsible for the breakdown of lipid
peroxides before they accumulate on LDL-c.
The present study is carried out to investigate paraoxonase activity
and lipid profile in patients with chronic renal failure under hemodialysis.
The present study was conducted on 75 subjects. They were classified
into the following groups:
1. Control group (group I).
2. Short-term hemodylized patients (group II).
3. Long-term hemodylized patients (group III).
All the studied individuals were subjected to full history taking and
clinical examination.
The results of the present study revealed:
Significant decrease in serum basal paraoxonase activity, NaClstimulated
paraoxonase activity, cholesterol concentration, HDL-c
concentration, basal paraoxonase / HDL-c ratio and NaCl-stimulated
paraoxonase / HDL-c ratio in group II and group III in comparison
with group I.
Significant increase in serum creatinine, urea and triglycerides in
group II and group III in comparison with group I.
Summary and Conclusion
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Significant positive correlation in group II and group III between basal
paraoxonase activity and
* NaCl-stimulated paraoxonase activity.
* NaCl-stimulated paraoxonase / HDL-c ratio.
* Basal paraoxonase /HDL-c ratio.
Significant positive correlation in group II and group III between
NaCl-stimulated paraoxonase activity and:
*Basal paraoxonase activity / HDL-c ratio.
*NaCl-stimulated paraoxonase / HDL-c ratio.
Significant positive correlation in group III between HDL-c
concentration and :
*NaCl-stimulated paraoxonase activity.
*Basal paraoxonase activity.
In conclusion, the results of the present study in keeping with evidences
from literature revealed that paraoxonase enzyme activity decreases in
patients with chronic renal failure on regular hemodialysis and they have
greater risk of premature atherogenesis due to decreased HDL-c
anti-oxidant capacity.