الفهرس 
History of renal transplantationOnly 14 pages are availabe for public view
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Abstract
Renal transplantation is the procedure of choice for most patients with end-stage renal disease (ESRD), since it improves the quality of life. The rapidly increasing incidence of renal failure and the inadequate supply of kidneys, especially from cadavers, have created a wide gap between kidney supply and demand, which has resulted in long waiting times as well as an increasing number of deaths during the dialysis-dependency period. We have expanded our donor pool by performing renal transplants from genetically unrelated donors.
The present work was designed is to compare the long-term results of kidney transplantation from living unrelated donors (LURDs) with that from living related donors (LRDs)regarding graft and patient survival.
This study comprised 1735 kidney transplant recipients who received their grafts between March, 1976 and November, 2005 at Mansoura Urology and Nephrology center. Out of them, 1433 received their grafts from LRDs,while the other 302 received their grafts from LURDs.
On comparing both groups (related versus unrelated) the following were concluded:
1- The patient survival was comparable in both groups.
2- The patient survival was affected by many factors like age of the the recipient, medical co morbidities and post transplant medical or surgical complications.
3- The graft survival was lower in the unrelated group, but statistically was not significant.
4- Graft survival was affected by other factors like age of the donor, degree of HLA compatibility, original kidney disease, number and severity of acute rejection episodes.
Finally we concluded that kidney donation by volunteers who are genetically unrelated to their recipients is medically successful, socially valuable, and ethically acceptable provided the donors are healthy, altruistic, competent, and well informed. Given these considerations, and the severe shortage of kidneys available for transplantation, it is not surprising that the number of unrelated living donors is growing. While most of these donors are emotionally related to their recipients, a few are complete strangers . Because of favorable ethical arguments and medical success, genetically unrelated living donors are now an important source of kidneys for transplantation and they should remain so at least as long as the supply of kidneys is inadequate.