الفهرس 
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Abstract
Atherosclerosis and CAD continue to be the major
health problems.· Although the manifestations usually do
not appear until later adult life they appear to have
their origins in childhood. To assess whether or not
familial hyperlipoproteinemia was more frequent in
-,children whose parents showed signs of coronary heart
disease in early adult life this study was performed on
119 children of healthy and diseased parents they are
divided into five groups :-
1- Group 1 :-
Consists of 33 children of healthy parents (21 boys
and 12 girls). Their ages ranged from 3 to 14 years.
2- Group 2 :-
Consists of 22 children of parents witn myocardial
infarction (16 boys and girls), their ages ranged from 3
to 14 ye e rs .
3- Group 3 :-
Consi:sts of 22 children of .parents with diabetes
mellitus (9 boys and 13 girls). Their ages ranged from 5
to 14 years.
4-
girls)
5-
4 :-
of 22 children of parents sUffering both
meliitus + myocardial infarction (20 boys and 2
ranged from 8 to 14 years.
5 :-
c)
d)
of 20 children of parents
mellitus + angina pectoris (10
girls). Their ages ranged from 6 to 14 years.
were sUbjected to
ul history taking especially family history of any
se, drug intake and status of their diet.
rement of height, body weight determination, then
lation of surface area and body mass index of each
ct.
ul clinical examination
venous blood sample was taken and centrifuged,
e serum the following were done.
- Serum triglycerides level
- Serum total cholesterol
having both
boys and 10
a)
b)
- Serum HDL cholesterol level
- Serum LDL cholesterol level
- Serum apolipoprotein A
- Serum apolipoprotein B
- Serum fructosamine level
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The results of this work showed :-
1- Elevation in the mean level of serum triglyceride in
sera of children of parents with myocardial infarction
(MI), diabetes mellitus (OM), diabetes mellitus +
myocardial infarction (DM + MI)” and those of parents
with diabetes mellitus + angina pectoris (OM+ AP) In
comparison to those of control group.
2- Elevation of t.ct a i ’ cholesterol level in sera of all
children of parents with myocardial infarction,
diabetes mellitus, diabetes mellitus + myocardial
infarction and diabetes mellitus + angina pectoris in
comparison to control group.
)- Level of serum HDLcholesterol is reduced significantly
in sera of children of parents with myocardial
infarction while it is elevated significantly only in
sera of ’children of parents with diabetes mellitus,
while in diabetes mellitus + myocardial infarction and
of those having diabetes mellitus + angina p~ctors, the
ellevation was insignificant.
4- The level of serum apol iprotien-A is
groups of children in comparison to
reduced in all
tha t of control
group.
5- Elevation of serum level of LOL cholesterol and apo B
in ”sera of children of parents with myocardial
infarction, diabetes mellitus, diabetes mellitus +
myocardial infarction and” in those with diabetes
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-16’1-
mellitus + angina pectoris in comparison to that of
control group.
6- No significant difference was detected in serum
fructosamine level in sera of children of all group in
comparison to that of control group.,
7- The level of lipoproteins and apolipoproteins is not
signi~icantly affected by the type of food and pattern
of milk feeding.