الفهرس 
Material and methodsOnly 14 pages are availabe for public view
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Abstract
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Summary and Conclusion
Testicular dysfunction as manifested ov
decreased libido. impotence and Infertility is well
recognized in patients with chronic renal failure.
Plasma testosterone concentration and its rate
of production are often low and there Is diminished or
absent spermatogenesis. These changes may be reversed
and ferti 1it v resorted after successful renal
transplantation.
Our work was done to study serum testosterone
(total and free fraction) and its role in pathogenesis
of impotence In chronic renal failure male patients.
This study was conducted on 40 patients. Twenty
of them were on regular hemodialysis. The other 20
patIents were subdivided into 2 groups. 13 patients on
conservative treatment with exogenous androgen and 7
patients on conservative treatment without androgen
therapy.
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Fifteen healthy individuals were used asa control
group.
For all cases. The following had been done.
a- Full medical history.
b- Full clinical examination.
c.. Serum urea and creatinine.
d- Serum total and free testosterone by radioimmunoassay.
The results obtained showed:
1- Significant decrease of both total and free
testosterone in regular hemodialysis patients compared
to the control group.
2- Significant decrease of both total and
free testasterone in patients treated conservativelY
without exogenous androgen when compared to the
control group.
3- High significant increase of both total and free
testosterone in patients treated conservativelY with
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exogenous androgen when compared to the control group.
4- Significant increase of both total and
testosterone in regular hemodialysis patients when
compared to patients treated conservatively without
exogenous androgen.
5- In conservative treatment patients. exogenous
androgen was associated with decreased potency.
6- No significant change in total testosterone level
between potent and impotent patients on regular
hemodialysis.
7- Interestingly we found that free testosterone level
was significantly decreased in impotent patients
compared to potent patients on regular hemodialysis.
We concluded that the decreased level of
testosterone in chronic renal failure patients is
corrected to some extent with regular hemodialysis.
The decreased level of free testosterone has a role in
the pathogenesis of impotence in these patients.
Parenteral
the level
exogenous androgen while greatly increases
of total and free testosterone. potency
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deteriorateS more. It is highly recommended to study
the free fraction of testosterone in the evaluation of
potency in chronic renal failure patients.