الفهرس 
Proliferative vitreorin opathy
Subject and methodsOnly 14 pages are availabe for public view
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Abstract
Many different filtering procedures have been performed 10 establish a
fistula between the anterior chamber and the subconjunctival space.
Glaucoma filtering surgery differs from most surgical procedures ill thai
inhibition of wound healing is desirable to achieve surgical success. In recent
years, several surgical and pharmacologic techniques have been introduced to
enhance glaucoma fill ring surgei}’.(Skula and Parrish 198i).
Filtering surgery usually fails as a result of post-operative scarring of
the filtering site. The scarring usually takes place on the external episcleral
surface and hampers the aqueous outflow through surgically created fistula.
rrrmiguchi et 01., 1989).
Fibroblastic proliferation and collagen deposition is all important
compouanr of healiug process and f excessive, may be largely responsible for
failur of filtration. Recently, new efforts have been directed toward agents
that would aile, the normal wound healing process following glaucoma
filtration. Several agents including 5.f1uorouracil, triamcinolone and smoorh
muscle inhibitor are known 10 be fibroblast inhibitors and are therefore, of
potential use in controlling excessive wound healing after glaucoma surgery
mlumenkmnz et ol., 1984).
The al11imelabo,iite 5-tluorO\Iracil (5-FU) is a fluorinated pyrimidine
analogue. il Cl1l1 inhibit fibroblast prcliferation in tissue culture and in animals.
Postoperative subconjunctival injection of 5.FlJ has been demonstrated to