الفهرس 
Chronic liver diseaseOnly 14 pages are availabe for public view
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Abstract
Summary
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SUMMARY
In this study we have tried to find out the
role of protein S in liver disease children and to
assess its contribution to coagulation state in chronic
liver disease.
We selected twenty cases with chronic liver
diseases. They were chosen from the Pediatric
Hepatology Clinic, Ain Shams University Hospitals.
Their ages ranged from one to 12 years.
They were categorized into two groups:
Group A: Chronic Active Hepatitis.
Consisted of 7 children (4 females and 3 males).
Their ages ranged from 2~ to 11 years with a mean
4.46 + 3.03 years.
Group B: Post-Bepatitic Cirrhosis.
Consisted of 8 children (3 females and 5 males).
Their ages ranged from 2~ . to 12 years with a mean
5.31 + 3.08.
Ten healthy sex and age - matched children were
studied as a control group (group C).
All the children were subjected to the following:
Full medical history, thorough clinical examination
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laboratory investigations including: Complete blood
picture, platelet count, PT, PTT, total serum proteins,
serum albumin and globulin, alkaline phosphatase,
transaminases, serum bilirubin and quantitative
measurement of total and free protein S level in plasma
by (ELISA).
In chronic active hepatitis, the PT was 17.14
+ 6.84 seconds. Platelet count 267.140 .±.15.614/cmm.
Total plasma protein S concentration 87% + 19.46. All
the liver functions were impaired.
Meanwhile in patients with post-hepatitic
cirrhosis, PT was 20.16 + 12.61 seconds, platelet count
221.880 + 98.560/cmm, total plasma protein S concentration
85.37%+ 29.02 and free protein S concentration
86.2~+ 20.06. All the liver function were impaired.
On the other hand, the results of the control
group revealed that PT was 11.5 .±.0.53 seconds, platelet
count 293.500 + 79.650/cmm, total plasma protein S
concentration 101.7%+ 10.79 and free plasma protein S
concentration 91.2%.±.11.53.
Statistical analysis of all results showed that;
PT was significantly altered in all pateints, compared
to the healthy controls, PTT was not significantly
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altered
controls.
decreased
control.
in all patients compared
Platelet count/crnm was
all patients compared
to the healthy
significantly
in to the healthy
There was reduced in the level of total plasma
protein S concentration in all diseased patients
compared with the control group and th~re was no significant
difference in the level of free protein S
concentration in all patients compared with the control
group. Also, total and free plasma protein S concentration,
in chronic hepatitis were not significantly
different from the control group.
In patients with post-hepatitic cirrhosis, there
was decreased in the level of total plasma protein S
concentration compared to the control group while free
protein S concentration was not decreased.
We can conclude that in all our cases of chronic
liver diseases, there is a significant disturbance
in coagulation, hemostasis and a bleeding tendency
as evidented by prolongation of PT, reduced platelets
level in addition to reduced total protein ·S”.
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