الفهرس 
Material and methodsOnly 14 pages are availabe for public view
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Abstract
Our study was carried out on 15 uremic non diabetic
patients, 10 males and 5 females, ranged in age
between 21 to 57 years (mean 37.5+11.8 years).
All the patients have been treated by regular hemodialysis
for periods ranged between 6 to 52 months(mean
21.4 + 14.02 months).
Intravenous glucose tolerance test was performed
for every patients as follows:-
1- Before and after hemodialysis.
2- Then before and after hemodialysis at the end of each
week during a period of 4 weeks during which every
patient was supplemented with oral vitamin C in a
dose of 100 mg/day.
At the same time, serum ascorbi~ acid was estimated
as follows :-
1- Before vitamin C supplementation.
2- Then weekly during the period of ascorbic acid supplementation.
Our results demonstrated that hemodialysis causes
a significant (P < 0.01) deterioration of glucose tolerance
before vitamin C supplementation •
•
We related this impairement of glucose tolerance
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during hemodialysis to the following factors :-
a) Serum electrolyte variations observed at the end of
dialysis.
b) Increased level of free fatty acids following heparin
injectiun during dialysis.
c) Low blood oxygen partial pressure commonly associated
with acetate dialysis.
d) Acetate overload.
e) Other factors as pancreatic polypeptide release in
response to acute hyperglycemia, increased level of
serum growth hormone and glucagon in uremic patients.
However, after vitamin C supplementation, glucose
intolerance observed during hemodialysis was gradually
improved until this improvement becomes significant (P<
0.05) at the end of the fourth week. In the same time
serum ascorbic acid level increased gradually and becomes
significantly improved at the end of the third week
(P < 0.05).
The improvement in glucose tolerance after vitamin
C supplementation was related to the ef~ect of ascorbic
acid on the oxidatiun of proteins for carnitine synthesis
which was found to cause a marked improvement in glucose
intolerance observed during hemodialysis.
We concluded that hemodialysis causes impaired glucose tolerance which can be corrected by oral vitamin
C supplementation in a dose of 100 mg/day.