الفهرس 
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Abstract
Itemodialysis, one of modern medicine techniques increased the life expectancy of many patients with end stage renal failure. Unworthy it is not free of many disadvantages . Many studies showed that blood-membrane interaction is an important cause of such side effects, so, development of
new generations of haemodialysis membranes became the point of interset to the workers in that field. The aim of this work is to spot light on cellular immune functions, complement and thromboxane levels in dialyzed patients using three different generations of membranes. Fourty five CRF patients under regular haemodialysis in addition to ten normal controls are classified into four groups :
G.I: 15 patients using cuprophane membrane in dialysis session.
G.II 15 patients using An 69 membrane in dialysis session.
G.III 15 patients using polysulfone membrane in dialysis session.
G.IV 10 normal controls .
The following investigations were done before and after dialysis :
1.Blood urea and serum creatinine.
2.Complete blood picture.
3.Monocyte functions (chemotaxis and phagocytos.
4.T-cell count and response to PHA.
5.Complement III and IV.
6.Thromboxane B2.
The results obtained showed the following :
Significant decrease in T.L.C. in all dialysis patients compared to controls, the most significant reduction occured on using cuprophane membrane followed by polysulfone membrane and lastly An 69membrane. This reduction reaches its peak at 1 hour after start of dialysis in the three membranes, This was also applied on neutrophils, lymphocytes and monocytes. Significant impairment of monocyte functions in all patient groups compared to controls either in quantity obtained from reduction in monocyte count or quality obtained from impaired monocyte chemotaxis and phagocytosis. This impairment is most significant in patients using cuprophane followed by polysulfone and lastly by An 69 Significant impairment of T-cell functions in all patient groups compared to controls either in quantity obtained from reduction in T-cell count or quality obtained from impaired T-cell response to PHA. This impairment :s most significant in patients using cuprophane followed by polysulfone and last.lv by An 69.
Significant decrease in C3 and C4 levels in all patient groups compared to controls This reduction is most significant in patients using cuprophane followed by polysulfone and lastly by An 69. Significant elevation in thromboxane B2 levels in all patient groups compared to controls This elevation is most significant in patients using cuprophane followed by polysulfone and lastly by An 69.
In conclusion, there is impairment of all measured cellular and humoral immune functions in addition to thrombotic disturbances in all dialysis patients being maximized in traditionally used cuprophane membrane followed by polysulfone, and lastly by An 69. So, we can conclude that An 69 membrane is considered a safer membrane for uraemic patients .