الفهرس 
Types of penicillin
Materials and methodsOnly 14 pages are availabe for public view
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Abstract
The inc i ctencl;I of t orrs ill t i~ ”’nd sor””e t hro;:at ,1.1\11 th!’! i r rec::urrrent are usually high in tgypt In dlJ agcg specially in young ~~e9. sometimes were ~cc~mpani8rt wlth po~t streptoco~~~l inf~~~tion ~lS rheum1l:tic: fever dnrl rh(lumatic: heart di:!ilease 5pecja~ly wi t.h c:ongerut”, I ••• noTM.l i 8 auch as verrt r i r-u t ar s.epf ~ I dfl tecTo .
The peniclJlin is the dramatiC: tre~t~nt ”’nO proDhyl~xi5 A~
10nQ” act. i ng pen i r: i I \ ] n <l’:lil1 fist recurr”nt o t ”’trept ococ ri’l I
]1’11’”,,-,-
tion SpBcHI,IIY in patientlOl with hi5tOrv ot active rheumatic rever Qr (”onC!”Hll tal anoma l t ~ sucn dS v~nt r l l;lI lar ;9”’Hlt.i’ll rie I Bet,
Durinq this study ~o sample5 were take” frqm tnroat ~wab~
””t p,,- f lerltR wi t. n to)~R i ( it j:3 (111 ,-:asl’lfll.
rl’1f>1lm1\t. t c h,,~rt. 0.1 ie ”Clse l 11 cages) rl et~ct. pen i c 1 1 1 i r1 t o 1 ”’I”a ncrr~n~ typlna ot or~l Mrrpnt~rn~~l In rhp~~ r~5~~.
s. f.I’foot”’ne~?:J R t ’t’fll n:=;: 44~ ~ no!. 1-)...-1. ; ncr • ~ ~of’n~ ~ r 1 v» ~;;:: r ,.-,1 1 II:=:
1;” 4’.~ drlo1. ” r o t erant ~t.ri\ln8 •~_6~. w”,r;: lC”,lat”,(j 1l”’:-’I’I h I:n:’l”’” ”,1’
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~tre?toC’OCc1 26 :’!tTd in~ 56% :i nc Iud \ nq 5 ’ 6~ngl,\ig 18 f’tr•a t nf! 64.3_ inclUding 2 ~e~itive Btr~i”S 11-1~. 10 tolerant strajn~ S5.6~ and 6 r~i~t~nt 8trainK 31.~ 1301at~d tram 3 case~ of acctive rheumdti~ fever 33.3%. 1 caSAd of rhe~tir. he~rt dis~d~e 63.6~. ~ caSeft of to~silitis lO~ ~nd 6 ~~~e8 of r~r.urrent tonn8iliti~ and ventrl~ular septal dAfect a~.7~ S. ~dlivarius» gtr~ins 2B_6~ including 1 ~en~itiV8 ~tratns R7.5~ and 1 senRitive strain 12.5$. wer~ i~ol~ted from 7 case6 ot ton~iliti3 19~ and 1 cas”, of recurrent tonsilitl.S ann. ventricular septa, detect 14.;~~, s. mut~n6 2 3train~ 7.1~ ineludinq 1 sensitive strain 50% anct 1 tol~rant str~in 50~. were isolated tr~ 1 caB~ Qf ton3iliti~ 10% and 1 ~age of rheu~tic he~rt disease 9.1*. all ca~~s wer~ tak~n from National H”,arl lnstitl:lte e.nd eX~lI\ined h4Cp.riolo’)gie””llY anrt biochemie~lly i~ becteriologi~al unit ot ~nalyai6 de~~rtment innc I udinq 2 rrnlUp!’l of agelt , Ttl’” t;. r8T_ I1TOUT’ aq”d 7-1,4 yp.~r!! anel.
tna ~eoond group ag~d 15-36 y~ars.
Thl! nact.erto\OCIlC,” 1 t e et. •• : c:1ep””d9 on ctet:e(’t inn ”f t h •• tyr’o; l1~emQ1YS1~ of blood ~Q~r by isolated 5tr~in9 ~Iph~ haemn,vtic (vlridillTH3 stro’lpl:or.o,”,,,i I i’lnd ty>t’” naelllnlyt i” ,-;r-n•nt”””’•I”’’’’ l”l?lemolyt.icus _ PY0g’ene>l) a”d <Ibi.litv to ter”t11ent lflct,”,s’O In !”Ia<;;CQnlcey agar (~nter<><;QGG i I . cry9ta 1 vi” l et b 1 0011 ~crar Il”5Ad ~C) ~el”ct~ve m~di~ tor s. pyogenes in addition to bi’lGltracin ~enn~i1:1V.lty to;,st. optochin 5<:nsitivo;, t.est nsed d8 dirt’<:>rlT\t.l,V,l.nn
.t.o.-:<lr:.::”i (nAQ’~t i Vf: re’lt I. ””t h tvr~- l ~’l”,r: I’l”ya l)r,..,r h I r0r <lTQ” t h o t - 92 -
t~st between ~neumococGi
(positive t~8t} and viridan~ $~rep-
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1’!I!lt. id10us organiOOl) and brdn M;:lr-t il’ltusio-n DrQth were u~d i1115 Sugp~nsion ot sel~cted orqan1sm to detect in~ibit1on. zon~ diameter as sensitivity. moder4te sensitivity OT re8igtant by i!lgr8!!1m.ent with I!Itandi”lrd tabl” (.71 with d. itt erant ant i b i ot. ’i C:I t nnclu4inq Erythromycin that i~ the b~st choice in treatrnept a~ hlqn sp.n~itive in all ~d$eS and types of ~trept~cOc~i. f~ilow~ with vancom¥ctne and clidamycin that are moderate Bensitive then qenntamYctn and ChI orOlmphenico l that are resistant: in me.jor-tty <:>f cases and moderat~ senl5~tive in ~inor or thew. The peni~iJlin tolaranc” detection as bacteriostatic only not ~e bacterccidal action ot penicillin ~as detected by addinQ beta lact~~9 soluution ater tfrat rtay of i~cubatlon at 31 °C followed by reinncUbationtor 24 ho~rs at 37 QC to detect tolerance d~ re~ro~th of colQnies ~n9tde the ~one of inhibition elther in nurober equal or- more than 10 colon1e~ and th~p m4ke a film stained with qr~m staIn to be 8ur~ t~t toler~pt 8train~ ~Ar-e only ~treptocOCCl not others. Biochemical te$ts ~r~ done for typi~q the ig~lqt~d strains ~f virictans str~pto~o~~i dep~nrlin~ on hydroly~i~ ~- arrqinin and starch Which ~re posjtlv~ ~njy S. ~~nauis ~nC na~~clVA
in othP.TS.
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in other!!! and ilcid. production trOlll. sorbi to 1 and 100 nil i tol t.hat were po~itive only in S. mutan9 and ~~qative in oth~rS, S.~al1variu5 ~trains W6r& negativa tQ all the6e bin~hemical
tal!lt9.
10 !l<:lmpll!1l woore t!!;ken t:rOll!. tlu”oat swabs of 10 n.orma I !llP~ parentty healthy as control. resulted B atrai~ of s. sanguis and 2 strains s. ~livarius.
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