الفهرس 
Material and methodsOnly 14 pages are availabe for public view
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Abstract
SUMMARY
This study was conducted on 39 cases proved to have bright
liver on sonographic basis and fatty liver on histopathological
examination. As well as 12 cases with no sonographic evidence of
fatty liver. All cases submitted to complete clinical assessment,
laboratory investigations with special emphasis on serological
markers for hepatitis C virus, lipid profile, blood sugar and body
mass index.
This study showed that fatty liver was a disease of both sexes
(M: F ratio I: 1.05), it occurs mostly in forth and fifth decades of life.
As regards physical examination, hepatomegaly was present in
76.9% of the patients. Laboratory investigations showed that ALT
level was high in (71.8%) and AST level was high in (46.1%) the
ASTI ALT ratio was less than one.
Ultrasound examination IS of great value in detecting hepatic
fatty infiltration, however, the diagnosis can be established
definitively by liver biopsy and histopathological examination.
Fatty liver was found in all cases with chronic hepatitis C virus
infection (56.4%). There was significant correlation between
positive hepatitis C virus infection and body weight and the mean
body mass index in cases with positive HCV antibody or antigen
was significantly lower than the mean body mass index in cases with
negative hepatitis C virus. HCV positive cases (antibody or antigen)
had cholesterol levels higher than cases with negative HCY cases,
therefore the findings of the present work seem to suggest that the
pathogenesis offatty liver in HCY positive patients is multifactorial.
It may be a direct viral effect and other metabolic factors are also
important and potentiate this effect.
Thirty percent of the cases had obesity as non alcoholic fatty
liver disease increases by a factor of 4.6 in obese people and this is
due to reduction in insulin sensitivity, with decreased insulin effects
on both glucose and lipid metabolism.
Thirty five percent of the patients had type II diabetes mellitus
and this may be due to high concentrations of circulating free fatty
acids and the presence of type II diabetes mellitus significantly
increase the risk and severity of non alcoholic fatty liver disease.
As regard hyperlipidemia twenty six percent had low level of
highdensity lipoprotein. Collectively speaking most patients of fatty
liver have multiple risk factors, including HCV, obesity, type 2
diabetes and hyperlipidemia.
Sixteen percent of the patients with fatty liver were
asymptomatic. The most common complaints were right
hypochondrial pain, dyspepsia, fullness and easy fatigue .
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