الفهرس 
Introduction and aim of workOnly 14 pages are availabe for public view
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Abstract
Thrombocytopenia is a relatively common feature in chronic liver
disease. Many patients with chronic liver disease and greater than one
third of patients with cirrhosis have significant thrombocytopenia (Brophy
et at, 1996).
Theories about the underlying pathogenic mechanisms, mostly
centering on splenic sequestration and distruetion of platelets, have failed
!.O solve the problem so far (Peck-Radosavljevic et al; 1997) as it is often
difficult to demonstrate a correlation between platelet couot and spleen
size, thus additional factors probably contribute to the depressed platelet
count (Brophy et al., 1996).
Immnaologioal disturbances are commonly a feature in chronic liver
disease, including hyperglobulinaemia and the presence of autoantibodies
and circulating immune complexes and immme mechanisms eonld
therefore contribute to thrombocytopenia (deNoronha et al., 1991).
Many studies have reported elevated levels of antiplatelet antibodies
In patients with chronic liver disease. These findings suggest that an
immune mechanism may participate lin inducing or aggravating the
thrombocytopenia (Pereira ell. al., 1995).
Also, annohospholipid antibodies seem to be frequently associated
with chronic liver disease of various causes (Biron et aI., (998).
Antieardiolipin antibodies (IgG) ale frequently found! Hi patients with
chronic hepatitis C and may be implicated in the occurrence of thrombosis
and in the development ofthrombocytopenia (Prieto et al., 1996).