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Abstract Malnutrition diseases in infancy and childhood represent a major intetnational economic and public health problem. 1n Qur country, protein energy malnutrition ·PoE.M.” represents 47.3% of malnutrition diseases (Arab R,epublic of Egypt” 1979l. T~e effects of malnutrition on t~e buman tissues have been studied to a limited extent. The effect on the liver has been s,tu(lied by Goodhart and Shill1973j • The data indi,cate thOit in malnutrition, the deoxyribonucleic acid In A) and p~otein synthesis are reduced directly or $e~ondary to a change in t~e ribonucleic acid (RNA) metabolism in tissues of different organs. The alphal-~ntitrypsin is a glycoprotein synthesized by the liver of normal persons who at€!: homozygous for a mutant gene ,(Schultz et aL, 1966t Rueppers, 1972) 0 It is an acute phase reactant and is tbought to function as a major control prot.;!in!l9ainst the tissue-damaging effecl:c-s of both endogenous and exogenous enzymes (Tala:mo, Since information on the level of alpha1-antitrypsin in plasma of children suffering from P.E.M. is scanty, this work was planned in order to study the possible changes in pl.!l.slIIa alpha1-antitrYP2in in different forms of P.E.N. |