الفهرس 
Material and methodsOnly 14 pages are availabe for public view
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Abstract
Summary and Conclusion
Neonatal sepsis is a clinical syndrome of a systemic illness accompanied by
bactermia occuring in the first month of life.
Cytokines are a group of protein cell regulators, variously called lymphokines,
monokines, interleukines, and interferons.
The normal course of SIL-2Rs is to rise postnatally.Infection causes an acute
elevation in this soluble recptor .
Early and rapid diagnosis of neonatal sepsis is important for early initiation of
appropriate therapy.
This study was carried out on (50) neonates classified into:
Group (A..l;, Septicemic group with +ve blood culture consisted of (20) neonates .
Group 00: Septicemic group with -ve blood culture consisted of (20) neonates
Group (Q1 Control group consisted of (10) neonates.
All neonates were subjected to the following :
1- Full clinical evaluation including :
A-History taking.
B- Full clinical and physical examination.
11-Laboratory investigations which include:
A- Complete blood count (CBC) and hematologic scoring system (HSS).
B- C-reactive protein (CRP) .
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C- Erythrocyte sedimentation rate (ESR).
D- Blood culture (BC).
E- Measurement of the serum level of SIL-2Rs .
The most prominent clinical feature of septicemia were poor feeding (90%),
respiratory distress (67.5%), poor reflexes (67.5%) lethargy (57.5%), hyperthermia
(35%) and apnea (35%).
CRP was +ve in (18) cases (90%) in septicemic +ve culture neonates and +ve in
(17) case (85%) in septicemic -ve culture neonates and was -ve in all control neonates.
In septicemic +ve culture neonates, the lIT ratio was the most sensitive (95%)
followed by JIM ratio (85%) and TPMNs (80%).
In septicemic -ve culture neonates, lIT ratio and TPMNs were the most specific
tests (90%) each, followed by JIM ratio (80%) and IPMN (60%).
In our study, all septicemic neonates (+ve and -ve blood culture) had +ve HSS
>3 and all controls had -ve HSS <3.
Organisms isolated by blood culture in septicemic +ve culture neonates were
strept, agalactyia (25%), E-eoli (20%), staph. aureus (15%), staph. epidermidis and
isteria monocytogens (10%) each, strept. pyogens, pseudomonas aeroginosa, klebsiella
and enterococci (5%) each.
The measurement of serum level of SIL-2Rs in all neonates in this study showed
hat there was higher level of SIL-2Rs in all septicemic neonates than in controls. Also,
here is no great difference in the high level of SIL-2Rs in both septicemic +ve and -ve
nilture neonates.