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Abstract -82- Schistosomiasis is one of the world’s formost health problem. In Egypt, approximately 20 million individiua1s are sUffering from schistosomiasis ( Abd - E1-Wahab et a1., 1979) • The early lesions of intestinal bilharziasis are usually affecting the last few inches of the rectal wall withen reach of the sigmoidoscope (Arafa.,1962). Sigmoidoscopy and rectal snip is, therefore helpful especially in detecting active infection in the early localization stage, during asymptomatic intestinal bilharziasis and in chronic cases when the eggs are encapsulated in the tissue (EI-Shafei., 1962) • It is desirable to take several biopsy samples from the rectum because abnormalities can be patchy or not easily seen on endoscopy ( preston et a1., 1983) • The desi~~ of this stu~ was maL~ly intended to demonstrate the diagnostic value of sigmoidscopy -83- and the rectal snip tecr~ique in patients with presumed schistosomiasis • The subject of the present study comprises 150 cases which are divided into three groups. Group (A) with urine positive and stool negative for schistosome ova. Group (B) with stool positive and ur~ne negative for schistosome ova. Group (C) whth presumed schistosomiasis with urine and stool negative for ova. Almost 18 patients of group A and B were symptom free • This stress the importance of screening urine and stool analysis in individuals living in endemic areas. Clinical eXaminations, laboratory investigations and rectal mucosal biopsies at 10 and 20 em. levels were performed to all the cases. The present findings showed astatistical significant difference at 0.1% level between the results of urine and stool analysis when compared with that of the rectal mucosal biopsy. The rectal mucosal biopsy has the upper hand. -84- Mixed schistosomal infection were more prevalent than pure one, but it was not detected by urine and/or stool examination. The velue of such findings is mainly of help in having the right ’choice of the drugs that may be used in the treatment. The results also confirm that nlucosal biopsy at 10 cm level is most diagnostic significantly than at 20 cm level. The sensitivity of rectal snip at 10 em level was very p~gh( 98%) with false negativity of 2% when urine end stool were positive for schistosome ova. The predected value of rectal snip with negative urine and/or stool for schistosome ova was computed statistically with a result of ( 73.7%). This means that after urine , stool and rectal snip negativity for schistosome ova. there is only (26.3%) positivity that patient still harbour the infection. Finally this encouragement results of diagncEing presumed schistosomiasis should be used with spread using of the rectal snip method for diagnosis of closed infection. This particularly important in endemic areas. |