الفهرس 
Neonatal jaudice
Material and methodsOnly 14 pages are availabe for public view
 |  | from | 134 |  |  |
| | | from | 134 | | |
Abstract
-84-
SUMMAR AND CONCLUSION
Several studies have reported an increased incidence
of neonatal jaundice following the use of oxytocin for
induction or augmentation of labor. The mechanism of hyperbilirubinemia
,was investigated and contradictory results
were reported. Some authors reported that the use of
oxytocin for induction of labor is usually associated with
liver immaturity, anoxic liver’ damage, enhanced placentofetal
transfusion and increased red blood cell fragility.
The effect of electrolyte free solutions as glucose 5%
alone or with oxytocin on serum sodium and serum bilirubin
levels was controversial. Some reports suggested that
hyponatraemia was accompanied by an increased incidence of
neonatal hyperbilirubinaemi.a.
The present work consisted of 120 cases sUbjected to
labor augmentation. They were divided into 4 equal groups
each including 30 cases. The 4 groups were comparable as
regards maternal age, parity, gestational age and the
newborns wer~ comparable as regards birth weight and one
minute Apgar score. The dose of oxytocin was the same in
all cases (10 units). The first group received less than
500 cc normal saline, the second group received more than
1000 cc normal saline, the third group received less than
500 cc glucose 5% and the fourth group received more than
1000 cc glucose 5%.
-B5-
The study showed an increased incidence of neon~tal
hyponatraemia in the cases received
1000 cc and highly significant
maternal and cord serum sodium levels
glucose 5% more than
correlation between
in all groups (P
<0.01).
There is also a significant
between neonatal serum sodium and
negative correlation
serum bilirubin (P
<0.01) with an increased incidence of neonatal
hyperbilirubinaemia among hyponatraemic group.
Jaundice among cases who have normal serum sodium and
those received salt containing solution (normal saline)
during labor may be attributed to other mechanism of
actioR of oxytocin.
It is found that the use of electrolyte containing
solution as normal saline 0.9% and the use of glucose 5%
in volumes less than 500 cc during labor is attended with
a lower incidence of neonatal hyponatraemia and
hyperbilirubinaemia.