الفهرس 
Hepatosplenic schistosomiasisOnly 14 pages are availabe for public view
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Abstract
Summary and Conclueton
SU~~A~l’ and CoONCLUSloON
Schistosomiasis is a major health problem in Egypt. The disease is
commoner in lower Egypt especially the Northern parts of the Nile Delta
where S. mansoni exists, while it is rare in Upper Egypt where
haematobium predominants.
Every hacmostatic function may be impaired in patients with
hepatosplenic schistosomiasis, as the result of failure of both the
biosynthetic and clearance functions of the liver.
In bilharzial hepatic fibrosis, there is usually a hypocoagulable
tendency with bleeding due to defective synthesis of the coagulation
factors by the liver or due to their consumption in disseminated
intravascular coagulation.
Antithrombin 1Il and protein C are two major physiologic inhibitors
normally present in plasma and are both synthesized in the liver.
Antithrombin III was formely known as heparin co-factor and its
thrombotic action is catalyzed by heparin. It inactivates factor Xa and
other coagulation factors in addition to thrombin. Protein C, on the other
hand, is a vitamin K-dependent zymogen of a serine protease and was
initially named auto-prothrombin II-A. Activated protein C inactivates
factors Va and Villa.
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Summary and Conclusion
The aim of the work is to monitor antithrombin III and protein C
act iv itics in the compensated and decompensated stages of
schistosomiasis.
Twenty patients with hepatosplenic schistosomiasis mansoni and ten
wcll matched normal control constitute the subject of our study. The
selected paticnts were classified clinically into two groups. namely.
compensated non ascitic group and a decompensated ascitic group. each
consisted of ten patients.
All cases were subjected to full medical history and full clinical
cxamination. The following investigations were done: haemoglobin
percent. platelet count, prothrombin activity, partial prothrombin time,
serum albumin, total bilirubin, SOOT, SOPT, alkaline phosphatase, III
addition to antithrombin III and protein C in plasma.
IThe
folowing were reponed in our work:
There was a significant decrease in antithrombin III III both the
compensated and the decompensated bilharzial groups compared to
the control group.
) There was a significant positive correlation between antithrombin
JlI and both albumin and prothrombin activity. Also, a significant
ncgut ive correlation was found between antithrombin IJI and the
following: total bilirubin, SOOT, SOPT and serum alkaline
phosphatase.
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Summary ana Coricl u ei or;
3- There was a significant decrease in protein C in both the
compensated and the decompensated bilharzial groups compared
to the control group.
4- There was a significant positive correlation between protein C and
both albumin and prothrombin activity. Also, a significant negative
correlation between protein C and the following: total bilirubin,
SCIOT. SGPT. and serum alkaline phosphatase.
5- There was a significant positive correlation between PC and AT III.
6- The decrease of PC in hepatosplenic schistosomiasis was more
pronoUllced than AT Ill.
We call conclude from the study that the decrease of AT III and PC
had its impact 011 the pathogenesis in the coagulopathy state reported to
occur in patients with hepatosplenic schistosomiasis.