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Abstract
The thesis comprises four parts:
Part I: General Introduction:
This part comprises a brief idea about gastrointestinal disorders and GIT Drugs classification and mechanism of action.
Part II: simultaneous determination of Nifuroxazide and drotaverine hydrochloride in pure forms and in pharmaceutical preparation
This part includes a general introduction about the chemistry and mode of action of nifuroxazide and drotaverine hydrochloride, followed by a presentation of the reported methods used for their quantitative determination Experimental, results and discussion are also given.
This part comprises tree sections:
Section (A): Simultaneous determination of Nifuroxazide and drotaverine hydrochloride by the spectrophotometric method
In this section, nifuroxazide could be determined in presence of drotaverine hydrochloride using a zero order spectrum with an analytically useful maximum at 384.5 nm. The absorbance obeyed beer’s law over a concentration range 2-10 µg ml-1 with mean percentage recovery 99.82 ± 1.461 %.
The selectivity of the proposed method was checked using laboratory prepared mixtures and it was successfully applied to the analysis of the pharmaceutical formulation containing the above drugs with no interference from other dosage form additives.
The validity of the suggested procedure was further assessed by applying the standard addition technique.