الفهرس 
Low FlowOnly 14 pages are availabe for public view
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Abstract
Sevoflurane, a volatile inhalational anesthetic having the advantages of rapid induction and recovery, also of great use in pediatrics, was first synthesized almost 30 years ago by Wallin & Colleagus.
Sevoflurane is partly degraded by carbon dioxide absorbents to compound A, whose concentration increases in the anesthesia circuit with low flow sevoflurane (Eger et al. 1997).
The food and Drug Administration places no restrictions on sevoflurane anesthesia at high fresh gas flow rates, but the use of low flow sevoflurane anesthesia is still under investigations, this is partly because there is insufficient clinical data on low flow sevoflurane anesthesia and the nephrotoxic threshold of compound A in humans is uncertain, also there is a possible hepatotoxicity of compound A (Fukuda et al., 2004).