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Abstract
Dialysis patients constitute a high risk subset of patients for developing cardiovascular diseases. After stratification for age, race and gender, cardiovascular mortality is 10-20 times higher in dialysis patients than in general population. This is because presence of traditional risk factors such as hypertension, DM and dyslipidemia besides the non traditional risk factors such as anemia, hyperhomocystenemia,
Hyperfibrqnogenemia, oxidative stress, inflammation and dialysis procedure itself.
The inflammatory state associated with CRF plays a major role in development of atherosclerosis and CVD complications. Several inflammatory markers can be used to predict the CVD outcome in hemodialysed patients such as CRI\ homocysteine, fibrinogen and sialic acid.
Measurement of IISCRP is more helpful than CRP assay as it can detect lower levels which can be useful in prediction of cardiovascular events to guide us to the primary prevention.
This study was carried out to compare between sialic acid and HSCRP levels as markers of CVD in hemodialysed recipients.
This study was carried out on 120 individuals were selected from the inpatient Department of Internal Medicine, Menoufiya University Hospital and classified into three groups:
Group A (normal healthy volunteers served as controls), group B (hemodialysed patient with CVD) included two subgroups:!^ (duration of dialysis from 3 months up to one year) and B2 (duration of dialysis more than one year) and group C (hemodialysis patients without CVD) included two subgroups: C| (duration of dialysis from 3 months up to one year) and C2 (duration of dialysis more than one year).