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Abstract
In Egypt, breast cancer is the most common female malignancy in Alexandria, it accounts for about 47% of all malignancies in females. Early detection is the milestone in decreasing breast cancer mortality as it significantly do i main cause of cancer death.
Several categories of circulating tumor markers have been investigated in breast cancer including; classical tumor associated antigens such as CEA and CA 15-3; markers of tumor biology including markers of angiogenesis, adhesion and invasion; and antibodies response to tumor associated antigens as Her2/neu and p53.
Yet, There is no highly specific or sensitive marker in breast cancer. Nevertheless, many oncologists often utilize circulating tumor marker in various phases of this malignancy to obtain additional information about the disease extent and clinical course.
The aim of this study was to evaluate some biochemical parameters in breast cancer patients treated with CMF of FAC and to find markers that can be used as prognostic and/or diagnostic parameters in non-metastatic and metastatic breast cancer patients.
This study included 45 premenopausal females divuded into three groups: the first non-metastatic group included 15 females with recently detected breast caner of clinical stages II and III who received CMF of FAC as adjuvant chemotherapy after surgery. The second was the metastatic group, that included 15 premenopausal females with metastatic breast cancer before receiving second line chemotherapy. And the third group included 15 healthy females matched in age and menstrual state with the patient’s group.
Patients were followed up for six cycles of Chemotherapy. Blood samples were drawn before surgery, after two weeks of surgery (before stalling chemotherapy), after 3 and 6 cycles of treatment. In all samples, levels of ICAM-1 an CA 15-3 were evaluated in serum, GST in erythrocytes and GSH in blood.
This stgudy revealed that the levels of GST were increased n all studied groups but non of them was significantly difference form the control group. The higher levels of GST in breast cancer patients may be due to its role in drug detoxification. The values of GSH content revealed a significant decrease after surgery compared to before surgery and it normalized again after 6 cycles of chemotherapy. This amy be due to response to therapy.
CA15-3 level in non-metastatic breast caner were elevated but not significantly
different from control. But they were significantly elevated in the metastatic patients group.