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Abstract
Preeclampsia is a characteristic multisystem disorder of pregnancy and is a leading cause of maternal and perinatal morbidity and mortality.
Preeclampsia is characterized by hypertension, proteinuria and edema which are thought to be the result of diffuse en do the Hal activation and dysfunction.
Poorly perfused placental tissue may evoke the free radical process and occurrence of generalized lipid peroxidation.
Production of free radicals in endothelial cells is relatively low in normal conditions due to active defense systems including antioxidant molecules such as superoxide dismutase and glutathione.
Superoxide dismutase is responsible for the defense against superoxide anion radicals while glutathione is a general scavenger.
Hyperlipidemia can compromise endothelial function and may have a role in the promotion of oxidative stress and vascular dysfunction seen in preeclampsia.
This study was earned out to evaluate the role of some antioxidants like superoxide dismutase and glutathione and the extent of lipid peroxidation in the pathogenesis of preeclampsia.
This study was carried on 65 females: 50 preeclamptic patients (25 mild cases and 25 severe cases ) and 15 normotensive pregnant females served as control group.