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Abstract
Schistosomiasis is a behavioural disease through human contact with water infested with carcariate. This is often due to a lack of choice and avalaibility of save water suppliers for recreational and domestic purposes. So, schistomiasis remains a serious world health problem.
In this work, hematopophyrin (HP) was evaluated against B. alexandrina, the snail vector of schistosoma mansoni in Egypt, as a photomolluscicidal agent. This class of compounds is friendly to the environment with a high photosensitizing activity tpwards biological systems. Porphyrins have been already approved for medical use in the photodynamic therapy of tumors and other diseases.
Therefore, the snails and their eggs were incubated with concentrations of HP, then exposed to direct sunlight or solar simulator light for different periods. Also, HP molluscicidal properties were determined at certain water temperature, pH values, and water depth. Therefore, HP was tested for the forst time against these snails under simulated natural conditions in the TBRI experimental ditches at the Snails Research Station in El-Qanater El-Khayria, Qaluobia Governorate. In addition, the survival and growth rates of B. alexandrina snails hatched from the eggs previously exposed to He-Cd laser (405 nm) were calculated.
The results revealed that the appropriate incubation periods of snails and their eggs with HP were 12 and 21 hours, respectively. Also, the effective exposure period of HP-incubated snails and their eggs to light was 4 hours with an irradiance of 450 and 350 W/m2, respectively, and the sunlight was more effective than solar simulator one. However, 250 Q/m2 solar simulator light for 7 hours of exposure degarded HP to inefficient value.