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Abstract Heart rate variability has been recently recognized as an important independent prognostic factor after an acute myocardial infarction. Survivors of acute myocardial infarction with low heart rate variability at the time of discharge have a higher mortality rate than patients with high heart rate variability. The aim of the present study was to evaluate the correlation of heart rate variability with the extent of coronary artery disease and clinical variables including electrocardiographic changes in patients with acute myocardial infarction. Thirty patients (18 males (60%) and 12 females (40%)) with a mean age of 52.7 ± 7.44 years admitted with acute myocardial infarction were included in the present study. Tn addition, 10 age-matched healthy volunteers (6 males (60%) and 4 females (40%)) with a mean age of 50.7 ± 6.88 years served as a control group. All patients were subjected to 24-hours Holler monitoring during the First 24-48 hours of admission. Non of the patients iya |